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《Chongqing Medicine》 2016-03
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Expression and significance of VEGF and Bax in non-small cell lung cancer

Cao Wenrong;Yan Wenxiu;Wang Xueli;Department of Pathological,Eighth People′s Hospital of Qingdao City;  
Objective To investigate the expression of vascular endothelial growth factor(VEGF)and Bax in non-small cell lung cancer(NSCLC)and clinical value.Methods Paraffin specimens were collected from 80 cases of NSCLC tissues(NSCLC group)and 20 cases of normal lung tissue adjacent to benign lesions(control group).Western blot and immunohistochemistry were used to dectect the expression of VEGF and Bax.The relationship of the expression of VEGF and Bax with histological classification,stage,lymph mode metastasis were analyzed.Results The expression of VEGF in NSCLC group was higher than that in control group,the differences were statistically significant(P0.05).The higher expression of VEGF in the group of stageⅢ-Ⅳ was obtained than that in the group of stageⅠ-Ⅱ(P0.05).The higher expression of VEGF in the group with lymph mode metastasis was obtained than that in the group without lymph mode metastasis(P0.05).The expression of VEGF was not found to be related with histological classification(P0.05).The expression of Bax in NSCLC tissue was lower than that in normal tissue,the differences was statistically significant(P0.05).The lower expression of Bax in the group of stageⅢ-Ⅳ was obtained than that in the group of stageⅠ-Ⅱ(P0.05).The lower expression of Bax in the group with lymph mode metastasis was obtained than that in the group without lymph mode metastasis(P0.05).The expression of Bax was not found to be related with histological classification(P0.05).The expression of VEGF was negatively correlated with Bax in NSCLC(P0.05).Conclusion The expression of VEGF played a promoting effect in the NSCLC,and was negatively correlated with the expression of Bax protein,and the expression of the two could provide a basis for the diagnosis and prognosis of NSCLC.
【CateGory Index】: R734.2
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