Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2016-03
Add to Favorite Get Latest Update

Establishment renal calculus rat model induced by calcifying nanoparticles

Su Hongwei;Wang Jie;Zhu Yongsheng;Deng Qingfu;Pei Lijun;Wang Juan;Department of Urology,the Affiliated T.C.M Hospital of Luzhou Medical College;Department of Urology,the Affiliated Hospital of Luzhou Medical College;  
Objective To establish renal calculus rat model induced by calcifying nanoparticles.Methods We extracted and cultivated calcifying nanoparticles from clinically diagnosed patients with nephrolithiasis.Forty adult male SD rats were divided into4groups(n=10each):group A(given an intravenous injection of calcifying nanoparticles),group B(given an intravenous injection of calcifying nanoparticles and taken Shenshitong granules),group C(given an intravenous injection of calcifying nanoparticles and intraperitoneal injection of gallium nitrate),group D(as normal control).Eight weeks later,all rats were sacrificed.The kidneys were examined for pathology.Results Histopathological studies revealed calcifying nanoparticles induced renal tubular epithelial cells fatty degeneration and renal tubular crystallization,and caused renal interstitial infiltration with inflammatory cells.The formation of renal crystals in group A was more obvious than those in group B and C(P0.05).In group D,no crystals were formed and no pathological changes occurred.The levels of urinary calcium and urinary creatinine(of All group)at one day before the observation period(T_2)were higher than those at 4weeks after injection(T_1)(P0.01).The levels of urinary calcium and serum creatinine in group A and B and C were significantly higher than those in group D at T_2(P0.05).The levels of urinary calcium in group B and C were lower than that in group A at T_2(P0.05).However,there were no apparent differences of the levels of serum calcium and urinary creatinine between groups at T_2(P0.05).Conclusion Calcifying nanoparticles could cause renal tubular epithelial cells injury,which leads to the formation of kidney stones.
【Fund】: 四川省科技厅资助项目(14JC0105);; 四川省卫生厅资助项目(100288)
【CateGory Index】: R692.4;R-332
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 YU Cheng-fan,HUANG Xiao-bo,CHEN Liang,XU Qing-quan,HU Wei-guo,WANG Xiao-feng(Department of Urology,Peking University People's Hospital,Beijing 100034,China);Effect of nanobacteria on cell damage and crystal retention in renal tubular epithelial cells[J];Journal of Peking University(Health Sciences);2010-04
2 LI Xiao-ran,YUE Zhong-jin,PEI Wei,MA Jun-hai,WANG Wen-yun,XIN Wen-hu,MING Xing,YANG Xiong(Department of Urology,the Second Hospital of Lanzhou University,Lanzhou 730030,China);Comparison of four renal calcium oxalate calculus rat models[J];Journal of Modern Urology;2013-04
Chinese Journal Full-text Database 4 Hits
1 Tang Jinyuan,Zhou Zhansong,Shen Xuecheng,Yuan Yufeng(Institution of Urology,Southwest Hospital,Third Military Medical University,Chongqing,400038,China);Rapid detection and clinical evaluation of nanobacteria infection in type Ⅲ prostatitis[J];Journal of Third Military Medical University;2011-06
2 Su Hongwei;Zhu Yongsheng;Deng Qingfu;Chen Tongliang;Department of Urology,the Affiliated Hospital of Luzhou Medical College;;Detection of nanobacteria in serum,urine and calculus of patients with upper urinary calculi[J];Chongqing Medicine;2013-31
3 WANG Shi-guang;WANG Zhen;WANG Yang-min;YANG Xu-kai;LI Wei-ping;LAN Tian;HAN Xiao;Department of Urinary Surgery,the Second Hospital of Lanzhou University;Department of Urinary Surgery,Lanzhou General Hospital of Lanzhou Military Area;;Effects of the Fructus Lycii,Alismatis Rhizoma and Their Mixture on Urinary Stone Formation in Rats[J];Medical & Pharmaceutical Journal of Chinese People's Liberation Army;2014-09
4 WANG Yue;ZHANG Li;HAO Zongyao;LIANG Chaozhao;Department of Urology,First Affiliated Hospital of Anhui Medical University;Institute of Urology,Anhui Medical University;;Nanobacteria and the research progress of its effect on urinary stone formation[J];Journal of Clinical Urology;2015-07
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Li Chengwen~1,Sun Guang~1,Deng Yaoliang~2,Li Shengkuan~2,Mi Hua~2,Liu Deyun~2(1.Department of Urology,The Second Affiliated Hospital of Tianjin Medical University,Tianjin 300211;2.Department of Urology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Damage of calcium oxalate crystal to renal epithelial cells in rats[J];Journal of Modern Urology;2006-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved