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《Chongqing Medicine》 2016-03
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The protective effects of glutathione on renal oxidative damage induced by microcystin-LR on mice

Han Zhixia;He Meiyan;Cui Yan;Xiong Wei;Zhang Qingbi;Department of Environmental and Occupational Hygiene,Sichuan Medical University;Major of Preventive Medicine,School of Public Health,Sichuan Medical University;  
Objective To study the protection of glutathione(GSH)on renal oxidative damage to mice which caused by microcystin-LR(MC-LR).Methods Forty healthy KM mice were divided into five groups by randomly sampling,which were saline control group,GSH control group,MC-LR group,low dose GSH +MC-LR group and high dose GSH +MC-LR group,and the experiment was lasting 15 days by intraperitoneal injection.Then we took out the kidney for pathological observation and detected the activity of CAT,SOD,GSH-Px and the content of GSH,MDA.Results Compared with control group,the MC-LR increased the content of MDA[(2.31±0.22)nmol/mg prot,P=0.000]and decreased the content of GSH[(0.68±0.02)mg/g prot].The activity of CAT[(320.54±38.99)nmol/mg prot],SOD[(180.93±15.30)U/mg prot],GSH-Px[(295.11±42.40)U/mg prot](P0.05).However,after GSH was given,compared with MC-LR group,MDA content[(1.94±0.12)nmol/mg prot]of high dose GSH+MC-LR group significantly decreased(P0.05),GSH content[(1.01±0.08)mg/g prot,(1.08±0.16)mg/g prot]and CAT activity[(383.46±21.98)nmol/mg prot,(428.50±28.61)nmol/mg prot]of both GSH groups significantly increased(P0.05),the activity of SOD[(222.01±11.51)U/mg prot]and GSH-Px[(358.37±20.29)U/mg prot]of high dose GSH +MC-LR group significantly increased(P0.05).Conclusion MC-LR may cause renal oxidative damage through promoting the lipid peroxidation on renal cells.The GSH may reach a certain protective effect on kidney by reducing the lipid peroxidation,improving the antioxidant activity,and removing oxygen free radicals.
【Fund】: 四川省卫生厅自然科学基金项目(120384);; 泸州医学院大学生科研项目(2012075)
【CateGory Index】: R285.5
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