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《Chongqing Medicine》 2016-03
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The influence of Turbidity-reducing Granule on the intestinal immune function of rats with chronic renal failure

Wang Jian;Wang Qing;Ji Qin;Department of Nephrology,the First People′s Hospital of Yunnan;Department of Internal Medicine,Yunnan University of T.C.M;Department of Nephrology,the First Affiliated Hospital of Yunnan T.C.M University;  
Objective To establish a rat model of chronic renal failure(CRF)by using 5/6subtotal nephrectomy method,then observe and evaluate the effect of Turbidity-reducing Granule on the intestinal immune function of rats with CRF.MethodsCRF model Wistar rats were divided into high,medium and low dose group,sham operation group,and model control group.respectively given Turbidity-reducing Granule 4.05,8.10,16.20g·kg~(-1)·d~(-1).Benazepril group was given 2mL/d(1.2mg/d)Benazepril suspension fed;model control group and the sham group are saline 2mL/d orally.The rats were observed before and after treatment of signs and general condition,serum BUN,Scr changes,and pathological changes were observed under microscope.ELISA method were used to detect serum and intestinal SIgA.Results Turbidity-reducing Granule reduced the level of serum BUN,Scr in rats with CRF,there were statistically significant differences of Benazepril group and high,medium,low dose of Turbidity-reducing Granule group compared with model group(P0.05).Compared with the model group,the intestinal SIgA of Benazepril group and low,middle,high dose of group increased significantly(P0.05);intestinal SIgA in,middle and high dose group were significantly increased compared with Benazepril group(P0.05).Conclusion Turbidity-reducing Granule could improve renal function and intestinal immune function.
【Fund】: 2013年云南省自然科学基金(2011FZ258)
【CateGory Index】: R285.5
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