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《Chongqing Medicine》 2016-03
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Expression of transcription factor Sp3 in hepatocellular carcinoma

Mo Weijia;Li Jia;Lu Huiping;Feng Zhenbo;Department of Pathology,the First Affiliated Hospital of Guangxi Medical University;  
Objective To research the expression of Sp3andβ-Catenin in HCC and study the assessable factors of them for prognosis in patients with hepatocellular carcinoma.Methods Western blot and RT-PCR methods were used to detect the expression of Sp3andβ-Catenin in HCC and the liver tissue beside tumor among 49 cases.We analyzed the difference of these two indexes expressed in HCC and the liver tissue beside tumor.Then we detected the correlation between these two indexes and the character of clinic pathology,and researched the correlation between Sp3 and the prognosis of HCC.Results The high expression rate of Sp3 in HCC was higher than that of liver tissue beside tumor(P0.05)according to Western blot and RT-PCR,the same toβ-Catenin(P0.05).Expression of Sp3andβ-Catenin were both related with size of tumor and degree of differentiation.Positive correlation existed between these two indexes according to Western blot method(r=0.681,P=0.000)and RT-PCR method(r=0.641,P=0.000).The prognosis of cases with high expression of Sp3 was poorer than the low expression cases(P0.05).Conclusion Sp3 plays a promoter role in occurrence of HCC,which is correlated with the grade malignancy of HCC.Sp3 might participated in occurrence and development of HCC via the Wnt pathway.
【Fund】: 广西区域性高发恶性肿瘤规范化诊治关键技术研究及应用示范(桂科攻1298003-2-5)
【CateGory Index】: R735.7
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