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《Chongqing Medicine》 2017-01
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Effect of curcumin on PI3K/AKT/mTOR in rats with cerebral ischemia-reperfusion injury

Lan Jin;Pan Jingfang;Department of Neurology,Yichang Municipal Central People′s Hospital/First College of Clinical Medical Science,Three Gorges University;  
Objective To explore the effect and mechanism of curcumin on rat cerebral ischemia reperfusion injury.Methods The rat model of cerebral ischemia reperfusion injury was constructed by the suture-occluded method.The effects of curcumin on cerebral infarction range,cerebral water content,neurological symptoms,cerebral histopathological morphology and expressions of PI3 K,AKT,p-AKT,m-TOR,MDA,CAT,GPX,SOD,Bcl-2,Bax,Caspase-3and Cleavage-Caspase-3were evaluated.Results Curcumin had the protective effect on cerebral ischemia reperfusion injury,could alleviate the neurological symptoms,decreased the cerebral tissue pathological morphological changes and cerebral water content,in addition,which could alleviate the expressions of MDA,Bax,Cleavage-Caspase-3,IL-6,MCP-1and TNF-αand increased the expressions of PI3 K,p-AKT,mTOR,Bcl-2,Caspase-3,CAT,GPX and SOD.Conclusion The curcumin pretreatment has the significantly protective effect on cerebral ischemia-reperfusion injury,which may be associated with activating PI3K/AKT/mTOR signal pathway,while suppressing inflammation,apoptosis and oxidative stress.
【Fund】: 湖北省宜昌市科技基金资助项目(A11301-05)
【CateGory Index】: R743
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