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《Chongqing Medicine》 2017-02
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Study on effect of blueberry probiotics for improving non-alcoholic fatty liver disease by influencing IL-22/JAK1/STAT3 signaling pathway

Zhu Juanjuan;Cheng Mingliang;Ren Tingting;Zhou Mingyu;Department of Infection,Affiliated Hospital of Guizhou Medical University;  
Objective To study the effect of blueberry probiotics on interlukin-22(IL-22)mediated Janus kinase-1(JAK1)/signal transducer and activator of transcription 3(STAT3)signaling pathway,and to further explore the potential mechanisms to improve non-alcoholic fatty liver disease(NAFLD).Methods Forty clean grade rats were divided into the normal control group(NG),model group(MG),blueberry group(BG),probiotics group(PG)and blueberry plus probiotics group(BPG).Except for the NG group(100% general diet),the fat liver model in the other groups was prepared by 12-week complex high fat diet.After the model establishment,the remained rats were divided into BG,PG and BPG groups for conducting 8-week observation.Results The liver index,alanine aminotransferase(ALT),aspartate aminotransferase(AST),triglyceride(TG),total cholesterol(TC)and low density lipoprotein(LDL)in the BPG group were significantly decreased compared with the MG,BG and PG groups(P0.01)and high density lipoprotein(HDL)was significantly increased(P0.01);in IL-22 detected by the enzyme-linked immunosorbent assay(ELISA):the protein level in the BPG group was significantly higher than that in the MG,BG and PG groups(P0.01);in the quantificational reverse transcription-polymerase chain reaction(qRT-PCR):the expressions of JAK1 and STAT3in the BPG group were significantly increased compared with the MG,BG and PG groups(P0.01),while cholesterol regulatory element-binding protein-1c(SREBP-1c)expression in the BPG group was significantly decreased(P0.01);in Western blot(WB):the expressions of IL-22,JAK1 and STAT3in the BPG group were significantly higher than those in the MG,BG and PG groups,while the expression of SREBP-1cwas significantly declined(P0.01).Conclusion Blueberry probiotics could effectively ameliorate the pathological tissue structure of NAFLD,attenuates hepatocyte steatosis,its mechanism may be that blueberry probiotics could increase expression of IL-22,activates the downstream signaling pathway of JAK1/STAT3,down-regulates the SREBP-1cgene expression and inhibits SREBP-1crole,enhances cholesterol metabolism,attenuates lipid deposit in liver,which may be an adjuvant scheme to treat NAFLD.
【Fund】: 贵州省科技厅社会攻关资助项目(黔科合SY[2010]3017号);; 黔东南苗族侗族自治州林业局科研基金资助项目(ZLYJZFCG-2012-7);; 贵州省卫计委科技项目(gzwjkj2016-1-02)
【CateGory Index】: R259
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