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《Chongqing Medicine》 2017-02
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Study of serum chemerin and hs-CRP in patients with nonalcoholic fatty liver disease complicating insulin resistance

Yi Yufang;Chen Chunlian;Department of Geriatrics,Affiliated Hospital of Guilin Medical University;  
Objective To detect the serum levels of chemerin and high-sensitivity C-reactive protein(hs-CRP)in the patients with nonalcoholic fatty liver disease(NAFLD)and homeostasis model assessment of insulin resistance(HOMA-IR),and to investigate the mechanism of chemerin in NAFLD.Methods The patients with NAFLD were divided into the NAFLD group(30cases)and the NAFLD+IR group(30cases);other 30 individuals undergoing the healthy physical examination were selected as the healthy control group.The serum levels of chemerin and hs-CRP were measured by ELISA and immunoturbidimetry,respectively.Meanwhile,the fasting plasma glucose(FPG)and fasting insulin(FINS)were detected,and HOMA-IR was calculated.Results The levels of serum chemerin and hs-CRP in the NAFLD group were increased obviously compared with the healthy control group(P0.05).The levels of serum chemerin and hs-CRP in the NAFLD+IR group were significantly increased compared with the NAFLD group and healthy control group(P0.05).The serum chemerin level was positively correlated with the hs-CRP level and HOMAIR.Conclusion The serum chemerin level is correlated with hs-CRP and HOMA-IR in NAFLD patients.
【Fund】: 广西教育厅科研基金资助项目(2013LX075 2013LX077);; 广西卫生厅科研基金资助项目(Z2013489);; 广西桂林市卫生局科学研究与技术开发计划资助项目(20120121-1-14)
【CateGory Index】: R575
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Chinese Journal Full-text Database 1 Hits
1 HUANG Zefeng;XIE Xin;Out-patient Department,General Political Department of Chinese PLA;Ministry of Education Key Laboratory of Resource Biology and Biotechnology in Western China,College of Life Science,Northwest University;Department of Translational Medicine,Institute of Integrated Medical Information;;Chemerin induces insulin resistance in C2C12 cells through nuclear factor-κB pathway-mediated inflammatory reaction[J];细胞与分子免疫学杂志;2015-06
Chinese Journal Full-text Database 3 Hits
1 Yi Yufang;Chen Chunlian;Department of Geriatrics,Affiliated Hospital of Guilin Medical University;;Study of serum chemerin and hs-CRP in patients with nonalcoholic fatty liver disease complicating insulin resistance[J];重庆医学;2017-02
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