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《Chongqing Medicine》 2017-02
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Study of serum chemerin and hs-CRP in patients with nonalcoholic fatty liver disease complicating insulin resistance

Yi Yufang;Chen Chunlian;Department of Geriatrics,Affiliated Hospital of Guilin Medical University;  
Objective To detect the serum levels of chemerin and high-sensitivity C-reactive protein(hs-CRP)in the patients with nonalcoholic fatty liver disease(NAFLD)and homeostasis model assessment of insulin resistance(HOMA-IR),and to investigate the mechanism of chemerin in NAFLD.Methods The patients with NAFLD were divided into the NAFLD group(30cases)and the NAFLD+IR group(30cases);other 30 individuals undergoing the healthy physical examination were selected as the healthy control group.The serum levels of chemerin and hs-CRP were measured by ELISA and immunoturbidimetry,respectively.Meanwhile,the fasting plasma glucose(FPG)and fasting insulin(FINS)were detected,and HOMA-IR was calculated.Results The levels of serum chemerin and hs-CRP in the NAFLD group were increased obviously compared with the healthy control group(P0.05).The levels of serum chemerin and hs-CRP in the NAFLD+IR group were significantly increased compared with the NAFLD group and healthy control group(P0.05).The serum chemerin level was positively correlated with the hs-CRP level and HOMAIR.Conclusion The serum chemerin level is correlated with hs-CRP and HOMA-IR in NAFLD patients.
【Fund】: 广西教育厅科研基金资助项目(2013LX075 2013LX077);; 广西卫生厅科研基金资助项目(Z2013489);; 广西桂林市卫生局科学研究与技术开发计划资助项目(20120121-1-14)
【CateGory Index】: R575
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 HUANG Zefeng;XIE Xin;Out-patient Department,General Political Department of Chinese PLA;Ministry of Education Key Laboratory of Resource Biology and Biotechnology in Western China,College of Life Science,Northwest University;Department of Translational Medicine,Institute of Integrated Medical Information;;Chemerin induces insulin resistance in C2C12 cells through nuclear factor-κB pathway-mediated inflammatory reaction[J];细胞与分子免疫学杂志;2015-06
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Yi Yufang;Chen Chunlian;Department of Geriatrics,Affiliated Hospital of Guilin Medical University;;Study of serum chemerin and hs-CRP in patients with nonalcoholic fatty liver disease complicating insulin resistance[J];重庆医学;2017-02
2 He Qing;Fan Chaohua;Yang Hongjie;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of TCM;;Research of Traditional Chinese Medicines Based on Regulating Adipokines to Improve Insulin Resistance[J];浙江中医药大学学报;2016-12
3 Liu Shu-yu;Pan Tao;Wang Jun;Ye Wo-ruo;Gong Jian-bin;Department of Cardiology,Nanjing General Hospital of Nanjing Command;;Effects of Ezetimibe on Fat Factors and Insulin Resistance in Db/db Mice[J];华南国防医学杂志;2016-11
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 WU Yang;TANG Xiao-hong;Dept. of Cardiology,the Third Xiangya Hospital of Central South University;;Advances of chemerin and metabolic syndrome and its related diseases[J];基础医学与临床;2014-09
2 ZHAO Dan-dan;MU Qian-qian;FANG Xin;ZHANG Dong-wei;MO Fang-fang;GAO Si-hua;Beijing University of Chinese Medicine;;Effects of Jiangtang Xiaoke Granule containing serum on insulin resistance C2C12 IR cells[J];中华中医药杂志;2014-05
3 JIAO Yi;CHANG Xi;WANG Li-Feng;Department of Biochemistry,Preclinical Medicine College,Xinjiang Medical University;;Effects of recombinant chemerin protein on visfatin and MCP-1 expression in 3T3-L1 adipocyte[J];中国老年学杂志;2014-02
4 YANG Jing,PEI Li-na,DU Jian,ZHAO Xiao-juan,LIU Hui-qiang,ZHANG Ying-yan(Department of Endocrinology,The First Hospital,China Medical University,Shenyang 110001,China);Expressions and Significance of chemerin mRNA in Adipose Tissue of Insulin Resistant Rats[J];中国医科大学学报;2012-01
5 LI Bing1,YANG Ju-hong1,WANG Hui-jie2,WANG Nan1,LIANG Dong-chun3,TAN Wen-jia4,FENG Ping1(1.Department of Metabolism,General Hospital,Tianjin Medical University,Tianjin 300052,China;2.The First Community For Retired Officer;3.Metabolic Disease Hospital,Tianjin Medical University;4.Norman Bethune College of Medicine,Jilin University);Expression of Chemerin mRNA in the adipose tissue of spontaneous type 2 diabetic rat[J];天津医科大学学报;2010-03
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