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《Chongqing Medicine》 2017-02
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The effect of aspirin on the expression of five miRNA in plasma of patients with unstable angina pectoris

Li Yun;Lv Yunbo;Song Yinhong;The College of Medical Science,China Three Gorges University;Department of Cardiology,People′s Hospital of Three Gorges University;  
Objective To detect the effect of aspirin on the expression of miR-21,miR-24,miR-126,miR-146 and miR-223 in plasma of patients with unstable angina pectoris(UAP).Methods Fifteen UAP patients with coronary artery disease and ten UAP patients without coronary artery disease were selected as subjects.All subjects had no medication of aspirin before.Aspirin entericcoated tablets was taken to all subjects at 0.1g once a day orally for one week.The peripheral blood(PB)samples of the patients were collected before and after taking the drug for one week.The expressions of the 5miRNAs in plasma were detected by quantitative reverse transcription PCR(RT-qPCR).Meanwhile,fifty UAP patients with or without coronary artery disease were divided into the aspirin group and the control group according to the medication of aspirin.The expressions of the 5miRNAs in plasma between different groups were compared.Results The expression of miR-223 in plasma of UAP patients with coronary artery disease was increased significantly after the medication of aspirin(P0.05).However,the expression of the other 4miRNAs in plasma of these UAP patients with coronary artery disease and the 5miRNAs in plasma of the UAP patients without coronary artery disease did not change significantly before and after the medication of aspirin(P0.05).Conclusion The medication of aspirin is able to increase the expression of miR-223 in serum of UAP patients with coronary artery disease but not of UAP patients without coronary artery disease.
【Fund】: 湖北省教育厅自然科学研究项目(Q20121306)
【CateGory Index】: R541.4
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Yimin;DU Lutao;WANG Lili;JIANG Xiumei;LI Juan;QU Ailin;WANG Haiyan;ZHENG Guixi;ZHANG Xin;YANG Yongmei;WANG Chuanxin;Department of Clinical Laboratory,Qilu Hospital of Shandong University;;Identification and validation of suitable reference genes for the investigation of serum microRNA in bladder cancer patients[J];山东大学学报(医学版);2014-05
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 ZHAO Yayun;ZHANG Yu;CAO Mingyue;HUANG Hongli;LI Juan;XUE Liangyi;Collge of Marine Sciences,Ningbo University;Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture,Ningbo University;;Selection and Evaluation of Reference Genes in Quantitative PCR Analysis of microRNA in Larimichthys crocea[J];核农学报;2017-07
2 Li Yun;Lv Yunbo;Song Yinhong;The College of Medical Science,China Three Gorges University;Department of Cardiology,People′s Hospital of Three Gorges University;;The effect of aspirin on the expression of five miRNA in plasma of patients with unstable angina pectoris[J];重庆医学;2017-02
3 LI Yun;SONG Yin-hong;LYU Yun-bo;QIN Qin;The People's Hospital of Three Gorges University;;Effect of blood-preserving time on expression of miRNAs in plasma of patients with unstable angina pectoris[J];山东医药;2015-41
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU Hui;DU Lu-tao;YANG Yong-mei;DONG Zhao-gang;LI Juan;LIU Yi-min;ZHANG Xin;WANG Li-li;ZHENG Gui-xi;WANG Chuan-xin;Department of Clinical Laboratory,Qilu Hospital of Shandong University;;Expression of miR-182 in colorectal cancer and its effect on the migration of colorectal cancer cells[J];山东大学学报(医学版);2013-12
2 ZHAO Meng1,LI Yue2,HOU Xin-xin1,ZHANG Gui-yu1(1.Department of Gynaecology and Obstetrics,Qi Lu Hospital of Shandong University,Jinan 250012,China; 2.Department of Gynaecology and Obstetrics,Weihai City Hospital,Weihai 264200,Shandong,China);The target down-regulating effect of miR-205 on PEG3 in endometrial cancer cell lines[J];山东大学学报(医学版);2013-04
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