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《Chongqing Medicine》 2017-02
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Expression and clinical significance of NF-κB p65,EGF and EGFR in oral lichen planus and oral squamous cell carcinoma

Zhou Cong;Wu Baoqin;Zhang Qimei;Wang Zhongchao;Department of Oral Medicine,Affiliated Stomatology Hospital,Southwest Medical University;  
Objective To investigate the expressions and significances of nuclear factor kappa B p65(NF-κB p65),epidermal growth factor(EGF)and epidermal growth factor receptor(EGFR)in oral lichen planus(OLP)and oral squamous cell carcinoma(OSCC).Methods The immunohistochemical technique with SP method was used to detect the expression of NF-κB p65,EGF and EGFR of oral mucosa in 20 cases of normal oral mucosa(NOM)tissue,20 cases of OLP tissue,and 20 cases of OSCC tissue.Results The expression rates f NF-κB p65 protein in NOM,OLP and OSCC were 10%,65% and 75%respectively,the difference among3 groups were statistically significant(P0.05).The expression rates of EGF in NOM,OLP and OSCC were 25%,45% and 65%respectively,the difference among 3groups were statistically significant(P0.05).The expression rates of EGFR in NOM,OLP and OSCC were 20%,55% and 70% respectively,the difference among 3groups were statistically significant(P0.05).The NF-κB p65 expression was correlated with lymph node metastasis(P0.05).The EGFR expression was correlated with the histological grades(P0.05).There was a positive correlation between expression of NF-κB p65 and EGFR in OLP(P0.05).There was a positive correlation between NF-κB p65 and EGF with EGFR in OSCC(P0.05).Conclusion NF-κB p65,EGF and EGFR might be one of the objective indicators of the early diagnosis of OSCC.
【Fund】: 四川西南医科大学资助项目(200903)
【CateGory Index】: R781.5;R739.85
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 XU Ye,XIA Xianyin,ZHAO Lingbo,MAN Zhaozhao,WANG Xiumei.150086 Haerbin,Department of Oral Medicine,the Second Affiliated Hospital of Harbin Medical University,China;Expression of Toll like receptor 4 and nuclear factor-kappa Bp65 in oral lichen planus[J];实用口腔医学杂志;2013-02
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Zhou Cong;Wu Baoqin;Zhang Qimei;Wang Zhongchao;Department of Oral Medicine,Affiliated Stomatology Hospital,Southwest Medical University;;Expression and clinical significance of NF-κB p65,EGF and EGFR in oral lichen planus and oral squamous cell carcinoma[J];重庆医学;2017-02
2 WANG Xue-ying;SONG Dian-kun;Fujian Medical University Union Hospital;;The expression of Toll like receptor 4 and TNF-α signal pathway in oral lichen planus lesion[J];实用医药杂志;2016-04
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Ruaidhrí J. Carmody1, 2 and Youhai H. Chen1 1Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;Nuclear Factor-κB:Activation and Regulation during Toll-Like Receptor Signaling[J];Cellular & Molecular Immunology;2007-01
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