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《Chongqing Medicine》 2017-02
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Impact of somatostatin on inflammatory factors and gastrointestinal function in elderly patients with early postoperative inflammatory intestinal obstruction

Shao Jianfu;Li Xinghai;Li Wen;Wang Jingxuan;Li Yanmei;Department of General Surgery,Tangshan Municipal People′s Hospital;  
Objective To study the impact of somatostatin on inflammatory factors and gastrointestinal function in elderly patients with early postoperative inflammatory intestinal obstruction.Methods Ninety-eight elderly patients with early postoperative inflammatory intestinal obstruction in our hospital form February 2014 to July 2015 were selected and divided into the control group and observation group according to the random number table method,49 cases in each group.The control group was given the conventional treatment,while the observation group was combined with the therapy of somatostatin Stilamin.Then the clinical curative effect,gastrointestinal function and inflammatory cytokines were compared between the two groups.Results The total effective rate in the observation group was 91.84%,which was significantly higher than 73.47%in the control group(χ2=4.555,P0.05);the anal exhaust recovery,abdominal symptoms relief,bowel sounds recovery and cure time in the observation group were significantly shorter than those in the control group(t=3.382,4.786,4.516,4.868,P0.05);serum CRP,TNF-αand IL-6levels were significantly lower than those in the control group(t=7.492,8.723,8.253,P0.05).Conclusion The somatostatin combined therapy conduces to recover the gastrointestinal function,reduces the intestinal inflammatory reaction and improves clinical curative effect.
【Fund】: 唐山市科学技术研究与发展指导计划(06134601c-16)
【CateGory Index】: R473.6
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