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《Chongqing Medicine》 2017-02
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Impact of pre-administration of rosuvastatin on level of myocardial reperfusion and vagus nerve function after primary PCI in STEMI patients

Lu Qing;Ding Shifang;Chen Zhinan;Jiang Jiequan;Gong Zhigang;Li Zhigang;Fu Wenbo;Department of Cardiology,Wuhan General Hospital of Guangzhou Military Region;  
Objective To investigate the impact of different rosuvastatin pretreatments on myocardial reperfusion and vagus nerve function in the patients with ST-segment elevation myocardial infarction(STEMI)taking long term administration of statins undergoing primary percutaneous coronary intervention(PPCI).Methods According to whether taking statins drugs for over 3months,170 patients suffered from STEMI for the first time were divided into the long term statins intervention group(n=45)、high dose pretreatment group(n=64)and conventional dose pretreatment group(n=61).CK-MB,TnT,hs-CRP,IL-6and lipids levels were detected before and after PCI.The myocardial reperfusion situation was evaluated.The deceleration capacity of rate(DC)and chemoreflex sensitivity(ChRS)were measured on postoperative 7,40 d.The occurrence of major adverse cardiovascular events(MACE)and adverse drug reactions were observed within postoperative 40 d.Results The long-term statins intervention group was significantly superior to the conventional dose group in the aspects of postoperative TIMI TMPG grade 3,RA(ventricular tachycardia,sinus bradycardia,atrioventricular block)occurrence,EKG elevated ST falling rate and reperfusion arrhythmia(P0.05);the DC value,low-risk value proportion and ChRS value on postoperative 7,40 din the two groups were significantly increased compared with the conventional dose group(P0.05),the high-risk value proportion was significantly decreased compared with the conventional dose group(P0.05).These two groups were superior to the conventional dose group in the aspects of angina pectoris reoccurrence,heart failure,severe ventricular arrhythmia(multiform PVC,non-sustained ventricular tachycardia)and color Doppler ultrasound LVEF.Conclusion Preoperative rosuvastatin 10 mg pre-treatment in the STEMI patients with long-term rosuvastatin administration can further increase the myocardial reperfusion level and vagal nervous activity,and improves the shortterm prognosis.
【Fund】: 武汉市中青年医学骨干人才培养工程(武卫生计生201477)
【CateGory Index】: R542.22
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