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《Chongqing Medicine》 2017-02
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Analysis on clinical immune function in patients with septic shock

Long Pan;Li Xiang;Jiang Lijing;Xia Zhuye;Wang Hui;Department of ICU,Minhang District Central Hospital,Affiliated Minhang Hospital,Fudan University;  
Objective To observe the changes of immune function in the patients with different severity degrees of sepsis and septic shock.Methods Sixty patients with septic shock(observation group)and 64 patients with sepsis(control group)were selected.The influence of sepsis on immune function was understood by observing the differences of the immune function between the two groups.Results Compared with the control group,T lymphocytes count in the observation group was decreased(P0.05).CD3+CD8+T lymphocytes in the observation group were decreased compared with the control group(P0.05).The difference of CD4+/CD8+ratio had statistical difference between the two groups(P0.05).The B lymphocytes count in the observation group was increased compared with the control group(P0.05).C4 and IgM had statistical difference between the two groups(P0.05).The WBC count,C reactive protein had statistical difference between the two groups(P0.05).The correlation analysis of procalcitonin concentration,complements and antibodies showed that complement 3had a correlation with procalcitonin(P0.05).Conclusion The severe immune function disorder exists in septic shock,including immune inhibition and autoimmunity trend.Meanwhile complement 3is correlated with the severity degree of septic shock,which has a potential value to judge the severity degree of septic shock.
【Fund】: 上海市闵行区自然科学研究课题(2016MHZ21)
【CateGory Index】: R459.7
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