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《Chongqing Medicine》 2017-02
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Study on correlation between adiponectin and it single nucleotide polymorphism with Zhuang metabolic syndrome in Guangxi

Zheng Liping;Yang Lan;Lu Junjia;Zhu Xu;Department of Clinical Laboratory,Nanning Municipal Second People′s Hospital;  
Objective To study the correlation between adiponectin(APN)and gene site APN+45,+276and-11377 polymorphisms with Zhuang metabolic syndrome(MS)in Guangxi Region.Methods The levels of serum adiponectin in Zhuang MS patients,Han MS patients,Zhuang normal people and Han normal people(each of 100cases)were detected by enzyme-linked immunosorbent assay(ELISA)method,and APN+45,APN+276and APN-11377 polymorphisms were detected by using PCRRFLP.Results(1)Compared with the same nationality normal control group,the APN and HDL-C levels of the two MS groups were significantly decreased,while BMI,FPG,systolic blood pressure,diastolic blood pressure,TC,TG and LDL-C were significantly increased,the differences were statistically significant(P0.05);(2)the TG and GG genotype frequency of APN+45loci in Zhuang and Han MS groups was significantly higher than that in the same nationality normal group,the differences were statistically significant(χ2=25.058,P=0.000;χ2=25.425,P=0.003).APN+276loci TG and GG genotype frequency in Zhuang and Han MS groups significantly higher than that of same nationality normal group,the differences were statistically significant(χ2=14.319,P=0.001;χ2=11.631,P=0.003).The heterozygosis degree of APN+276locus in the Zhuang and Han MS groups was significantly higher than that in the same nationality individuals,the difference was statistically significant(all P0.05).Most of APN-11377 locus in the 4groups was the wild type,although there was a slight difference in the distribution of allele frequencies,but the difference was not statistically significant(P0.05).(3)The serum APN level in the patients with APN+45TT genotype of the two MS groups was significantly higher than that in the patients with TG and GG genotype,and the differences were statistically significant(P0.05).The serum APN level in the patients with APN+276GG genotype was significantly higher than that in the patients with GT and TT genotype,and the differences were statistically significant(P0.05).Conclusion The APN+45G genotype and APN+276Tgenotype resulted in the decrease of serum APN level,which may be associated with the occurrence of MS in Zhuang and Han nationality.
【Fund】: 广西壮族自治区南宁市科技课题资助(20123135)
【CateGory Index】: R589;R440;R446.1
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