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《Chongqing Medicine》 2017-02
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Effects and safety of dulaglutide for treatment type 2 diabetes mellitus:a meta analysis

Yu Bin;Feng Bimin;Yi Fanqi;Zhong Xiaoyan;Huang Houqiang;Huang Yilan;School of Pharmacy,Southwest Medical University;Department of Pharmacy,Affiliated Hospital of Southwest Medical University;School of Nursing,Southwest Medical University;  
Objective To evaluate the effect and safety of dulaglutide for the treatment type 2diabetes mellitus(T2DM).Methods The databases of Cochrane,Pubmed,OVID,Medline,Embase,CNKI,Wanfang and VIP were searched to collect the literature on randomized controlled trials(RCTs)of Dulaglutide in treating T2 DM.The reviewer assessed the quality of the literature according to the Cochrane Handbook,and conducted meta analysis with RevMan 5.2software.Results Ten RCTs involving 6 699 patients were included.The meta analysis results showed that dulaglutide significantly reduced HbA1c[positive control group:MD=-0.32,95%CI(-0.42,-0.22),P0.01;placebo:MD=-1.07,95%CI(-1.16,-0.99),P0.01],FPG[positive control group:MD=-0.60,95%CI(-0.84,-0.36),P0.01;placebo:MD=-1.86,95%CI(-1.88,-1.84),P0.01]and body weight[positive control group:MD=-0.95,95%CI(-1.69,-0.21),P=0.010;placebo:MD=-1.31,95%CI(-2.13,-0.49),P=0.002].In the aspect of safety,the risk of hypoglycaemia and the incidence of total adverse reactions in the dulaglutide group was similar to the placebo group and positive control group(P0.05).Conclusion Dulaglutide is safe and effective for treaing T2 DM.
【CateGory Index】: R587.1
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