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《Chongqing Medicine》 2017-02
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Alprostadil combined with somatostatin in treating severe acute pancreatitis:a meta-analysis

Chen Zhuo;Liu Shengnan;Wu Kejian;Department of Gastroenterology,Affiliated Hospital of Xuzhou Medical University;Department of Gastroenterology,Xuzhou Municipal First People′s Hospital;  
Objective To systematically estimate the efficacy and safety of alprostadil combined with somatostatin in the treatment of severe acute pancreatitis.Methods The database of PubMed,Cochrane library,Web of Science,Wanfang,CBM and CNKI were searched to collect all the random controlled trials(RCT)on alprostadil combined with somatostatin in the treatment of severe acute pancreatitis,the retrieval time was from each database establishment to December 2015,and Meta-analysis was performed by using RevMan 5.3software.Results A total of 11 articles involving 927 patients were included.The meta-analysis results showed:compared with the control group,alprostadil combined with somatostatin could significantly improve the total effective rate[OR=5.45,95%CI(3.48,8.52),P0.01],shortened the relief time of clinical symptoms[MD=-15.20,95%CI(-18.17,-12.23),P0.01],promoted serum amylase recovery[MD=-26.59,95%CI(-29.85,-23.34),P0.01],promoted CRP recovery[MD=-23.95,95%CI(-27.68,-20.22),P0.01],promoted IL-6recovery[MD=-12.40,95%CI(-15.69,-9.11),P0.01],the difference between the two groups was statistically significant.Additionally,the adverse reactions incidence was low.Conclusion Alprostadil combined with somatostatin could promote the therapeutic efficacy and safety in the patients with severe acute pancreatitis,which is worthy of clinical promotion.
【CateGory Index】: R576
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【Citations】
Chinese Journal Full-text Database 10 Hits
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