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《Chongqing Medicine》 2017-04
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The expressions and related discussion of YKL-40 and IL-1β in the cartilage of knee osteoarthritis

Su Xiaoen;Sun Zhiqiang;Zhu Juan;Deng Haitang;Zhang Zhenqian;Feng Wenjie;Department of Orthopaedics,the First People′s Hospital of Zhaoqing city;  
Objective To study the expressions of YKL-40 and IL-1βin the cartilage of knee osteoarthritis(KOA),and analysis the possible relationship between YKL-40,IL-1βin KOA.Methods Thirty-eight patients diagnosed with KOA were selected in this hospital as observation group.Then select 30 articular cartilage cases in the same period due to knee injury knee joint examination or treatment of knee joint fracture surgery patients,referred to as the control group.According to KOA radiation and arthroscopic grading standards,the observation group was divided into 16 cases of mild group,10 cases of moderate group,11 cases of severe groups.Compare the expression levels of all patients including YKL-40,interleukin-1β(IL-1β),IL-6,tumor necrosis factor-α(TNF-α),while recording Mankin score and cell mortality.Results Expression of YKL-40,IL-1β,IL-6,TNF-α,Mankin scores and rate of cell death about observation group were significantly higher than control group,the indicators above in mild,moderate,severe group showed a trend of rising(all P0.05).And the expression levels of YKL-40 and IL-1βwere significantly positive correlation(r=0.738,P=0.000).In addition,The expression levels of YKL-40 had relation with IL-6(r=0.819,P=0.000),TNF-α(r=0.871,P=0.000)and Mankin score(r=0.832,P=0.000),cells mortality deposit(r=0.832,P=0.000).Conclusion Expression levels of YKL-40 and IL-1βwere significantly increased in cartilage of knee osteoarthritis patients,and there showed a significant positive correlation between YKL-40 and IL-1β.
【CateGory Index】: R684.3
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