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《Chongqing Medicine》 2017-05
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The value of HE4,CA125,and ROMA model in diagnosis of the ovarian carcinoma

Dong Dongli;Gu Jinsong;Zhao Shaojie;Tang Yan;Zhao Tingting;Department of Gynecology,the Affiliated Wuxi Maternal and Child Health Hospital of Nanjing Medical University;  
Objective To explore the value of human epididymis protein 4(HE4),cancer antigen 125(CA125)and the risk of ovarian malignancy algorithm(ROMA)in the diagnosis of ovarian cancer.Methods Electrochemical luminescence and Enzymelinked immunosorbent assay(ELISA)were used to determine the levels of serum HE4,CA125 in 56patients with ovarian carcinoma,73 cases of ovarian benign tumor and 50 health women,and the ROMA was calculated by HE4 and CA125levels depending on the menopause state,drawing the receiver operating characteristics(ROC)curve and calculating the area under the curve(AUC).Results The average levels of the HE4,CA125 and the value of the ROMA were(345.33±605.03)pmol/L,(701.46±1 500.30)U/mL,(58.72±31.00)%in the ovarian carcinoma group,(53.84±14.68)pmol/L,(44.25±45.81)U/mL,(10.80±6.75)%in the ovarian benign tumor group,and(46.03±10.26)pmol/L,(17.39±10.64)U/mL,(6.92±3.85)%in the health control group respectively,compared with the benign tumor group and the health control group,the ovarian carcinoma group were higher in HE4,CA125 and the ROMA value,and the difference were significantly(P0.05),whereas compared in the ovarian benign group and the health group,except the CA125 was higher in the benign group and the difference had statistical significance(P0.05),the HE4 level and the value of the ROMA had no statistical significance(P0.05).The sensitivities of the HE4,CA125 and ROMA were 71.43%,76.79%,89.28%,the specificities were 93.15%,53.42%,94.52% and the ROC-AUCs were 0.930,0.809,0.937 respectively.When the specificity for the diagnosis of the ovarian carcinoma was 95.00%,the sensitivities of the HE4,CA125 and ROMA were 80.40%,53.60%,83.90% respectively.Conclusion HE4 and CA125combined detection to calculate the ROMA can elevate the sensitivity and specificity for the ovarian carcinoma diagnosis.
【CateGory Index】: R737.31
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Yan,LIN Ying-Ying,ZHENG Yu-Hong,HU Min-Hua,CHEN Yan-Song.Clinical Laboratory Department of Fujian Tumor Hospital,Fujian Medical University,Fuzhou 350014,China;The evaluation of serum HE4,CA125 and ROMA index in accessing the risk of ovarian cancer[J];中国免疫学杂志;2013-02
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 MA Lan;SUN Ying;WANG Ping;GAO Fu-ping;Department of Clinical Laboratory,Gaochun People's Hospital;Department of Gynaecology,Gaochun People's Hospital;Department of Pathology,Gaochun People's Hospital;;HE4 and CA125 Combined with ROMA Index for Epithelial Ovarian Risk[J];标记免疫分析与临床;2017-06
2 HE Jing-jing;ZHAO Dong-mei;ZHOU Yu-zhen;ZHANG Yan;ZHENG Zun-rong;LIU Jing-yao;Clinical Laboratory,Heilongjiang Agricultural Reclamation Bureau General Hospital;;Diagnostic value of combined detection of tumor markers in ovarian cancer[J];中国卫生检验杂志;2017-08
3 Dong Dongli;Gu Jinsong;Zhao Shaojie;Tang Yan;Zhao Tingting;Department of Gynecology,the Affiliated Wuxi Maternal and Child Health Hospital of Nanjing Medical University;;The value of HE4,CA125,and ROMA model in diagnosis of the ovarian carcinoma[J];重庆医学;2017-05
4 CHEN Juxing;WU Shangjian;MO Xiaying;CHEN Shaoxuan;CHEN Ruili;The People's Hospital of Huaiji County;;The application value analysis of serum TSGF and ROMA index in patients with ovarian cancer[J];实验与检验医学;2017-01
【Secondary Citations】
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1 ZHAO Yan,LIN Mali,FENG Jie,FANG Xiangzhong,ZHU Lirong,HAN Jinsong,YANG Rui,ZHANG Guirong,LIU Guangzhi,DAI Shuzhen.(Department of Obstetrics and Gynecology,Peking University People's Hospital,Beijing 100044,China);To construct a mathematical table to predict the survival rate for the serous ovarian cancer patients with Cox proportional hazard regression methods[J];中国妇产科临床杂志;2011-01
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