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《Chongqing Medicine》 2017-05
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Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat

Yan Zhang;Department of Gynaecology,Kunshan Hospital Affiliated to Jiangsu University;  
Objective To evaluate the effect of pelvic adhesiolysis to prevent readhesion in the second look operation.Methods 30 rats underwent laparotomy incision of uterus to create intraperitoneal adhesions models.The animals were randomly divided into three groups:the first group:isotonic Na chloride(n=10);the second group:medical Sodium Hyaluronate(n=10),the third group:Oxidized regenerated cellulose.After 2-week recovery period,the animals were operated and intraperitoneal adhesions were assessed,then,all adhesions were released and set isotonic Na chloride,medical Sodium Hyaluronate and Oxidized regenerated cellulose.Again,After 2-week recovery period,the animals were killed and the intraperitoneal adhesions were assessed.Results After the first operation the three groups had significant difference(F=7.114,P0.05),After the second operation the three groups had no significant difference(F=0.280,P0.05).Conclusion Medical sodium hyaluronate and oxidized regenerated cellulose are effective methods to prevent postoperative adhesions.However,they are ineffective to prevent readhesion after adhesiolysis.
【Fund】: 2013年度昆山市科技计划项目(KS1349)
【CateGory Index】: R713
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