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《Chongqing Medicine》 2017-05
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Levels of heme oxygenase-1 and carbon monoxide and its significance in the Mycoplasma pneumoniae infection in children

Chen Xiaozhen;Wang Jiwu;He Chunzhi;Department of Pediatrics,the Affiliated Puai Hospital of Tongji Medical College,Huazhong Technology and Science University;  
Objective To explore the heme oxygenase-1(HO-1)content of carbon monoxide(CO)levels and clinical significance of Mycoplasma pneumoniae infection in children.Methods 219 cases of mycoplasma pneumonia from October 2013 to June 2015 in our hospital were divided into two groups,which were non-asthmatic group(156cases)and wheezing group(63cases),and the wheezing group were divided into two groups according to the presence or absence of hypoxemia and mild asthmatic group(39cases)and severe asthmatic group(24cases).HO-1content in the blood was measured by enzyme-linked immunosorbent assay,using dual-wavelength spectrophotometric determination of hemoglobin oxygen percentage of broken(COHb%),analysis of the differences between the groups.Results Children with blood COHb content wheezing group were(2.59± 0.40)% and HO-1levels were(1 813.24±28.34)ng/L and non-respite group were significantly increased,it had significant differences between the two groups(P0.05).Group of children with severe wheezing COHb content were(3.63±0.45)% and HO-1levels were(2 594.34±23.94)ng/L and mild wheezing group were significantly increased,it had significant differences between the two groups(P0.05).Positive correlation between blood COHb content and HO-1levels were significantly(r=0.733,P0.05).Conclusion Mycoplasma pneumoniae infection in children with wheezing blood COHb content and HO-1levels were significantly increased,and with wheezing exacerbation and showed an increasing trend,suggesting that CO and HO-1may be involved in Mycoplasma pneumoniae infection in children in the pathogenesis of wheezing,should lead to clinical attention.
【CateGory Index】: R725.6
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