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《Chongqing Medicine》 2017-05
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Comparison the cardiorespiratory system effects of propofol-remifentanil and etomidate-remifentanil sedation in older patients undergoing painless gastroscopy

Guo Bo;Tang Wei;Department of Anesthesiology,Chongqing Traditional Chinese Medicine Hospital;  
Objective To compare the cardiorespiratory system effects of propofol-remifentanil and etomidate-remifentanil sedation in older patients undergoing diagnostic gastroscopy.Methods 400 older patients undergoing painless gastroscopy in endoscopy center of our hospital were chosen and randomly received intravenous propofol-remifentanil or etomidate-remifentanil sedation and divided into propofol group(n=200)and etomidate group(n=200).The diagnosis,endoscopic insertion time,operation time,wake up time,hemodynamics,adverse reaction and satisfactory of patients in each group were observed.Results There were no difference between two groups in diagnosis(P0.05);the onset time was earlier in the etomidate group(P0.05).Systolic pressure and diastolic pressure in propofol group were lower than etomidate group during and after operation(all P0.05);the heart rate in propofol group were lower than etomidate group after operation(P0.05);meanwhile,the SpO2 in propofol group were lower than etomidate group during operation(P0.05).All adverse events in propofol group were higher than etomidate group(P0.05).Incidences of hyoxemia and injection pain were higher in the propofol group(all P0.05),while those of body quiver and myoclonus were higher in the etomidate group(all P0.05).However,Satisfaction of physician and anesthetist in the propofol group were better the etomidate group(all P0.05).Conclusion Etomidate-remifentanil administration for sedation undergoing painless gastroscopy resulted in more stable haemodynamic responses and less adverse events in older patients.Etomidate-remifentanil administration was worth to be popularized in older patients.
【CateGory Index】: R573
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