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《Chongqing Medicine》 2017-05
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Meta-analysis of the relevance between Megsin rs1055901,rs1055902 and rs2689399 polymorphism and susceptibility of IgA nephrology in Asian population

Ge Yating;Su Meiling;Song Jiazhi;Xiong Zuying;Hou Shuang;Clinical College,Shenzhen Hospital,Anhui Medical University &Peking University;Department of Nephrology,Shenzhen Hospital,Peking University;  
Objective To assess the association of three polymorphisms in Megsin(rs1055901,rs1055902 and rs2689399)and susceptibility of IgA nephropathy in Asian population.Methods We conducted a comprehensive search of electronic CNKI,VIP,WangFang Data,CBM,Pubmed,Web of Science and Google Scholar database on the association between Megsin rs1055901,rs1055902 and rs2689399 polymorphism and susceptibility of IgA nephrology in Asian population(last search update on 2 May2016).Stata 12.0software was used to calculate the odds ratio(OR)and 95%CI(confidence interval),as well as sensitivity and publication bias analyses.Results Six publications encompassing nine case-control studies were finally included,including 2 179 cases and 1 769 controls.Finally,no significant association between Megsin rs1055901 and rs1055902polymorphism and IgA nephrology in Asian population was identified,while a significantly decreased risk of IgA nephrology for rs2689399 polymorphism,was identified in Asian population(G and C:OR=0.754,95%CI 0.592-0.961,P=0.022;GG and CC:OR=0.506,95%CI 0.287-0.892,P=0.019;GG and GC+CC:OR=0.551,95%CI0.316-0.961,P=0.036).Conclusion Rs2689399 Gallele and GG genotype of Megsin may be the protective factors for IgA nephropathy in Asian population.
【Fund】: 深圳市科技研发资金(JCYJ20140415162543010)
【CateGory Index】: R692.3
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【Citations】
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【Co-citations】
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1 Ge Yating;Su Meiling;Song Jiazhi;Xiong Zuying;Hou Shuang;Clinical College,Shenzhen Hospital,Anhui Medical University &Peking University;Department of Nephrology,Shenzhen Hospital,Peking University;;Meta-analysis of the relevance between Megsin rs1055901,rs1055902 and rs2689399 polymorphism and susceptibility of IgA nephrology in Asian population[J];重庆医学;2017-05
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