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《Chongqing Medicine》 2017-05
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Genetic polymorphisms of 19 Y-STR loci in in the Han population in Northeast China and the cluster analysis of ethnic groups in northeast Asia region

Zhang Minglong;Zhang Yongji;Wei Xinqiang;Zheng Lihong;Department of Bio-Genetics,Qiqihaer Medical University;Department of Forensic,Yanbian University;Police Bureau of Jingyue District;  
Objective To investigate the polymorphisms of the 19Y-STR loci in the Han population in Northeast China,and analyze the genetic relationships of 15 ethnic groups in northeast Asia region,and to evaluate their forensic value and population genetic value.Methods The 19Y-STR unrelated Han males in 200 unrelated Han males in Northeast China were amplified with the Y-filer system,and the PCR products were analyzed by the 310 Genetic Analyzer.The AMOVA analysis,cluster analysis and MDS analysis were calculated by Arelquin3.11,Mega4.1and SPSS17.0.Results The polymorphisms of 19Y-STR loci in the Han population in Northeast China had generally higher gene diversity value which were ranged from 0.350 9(DYS391)to 0.971 1(DYS385a/b),and totally 200 haplotypes were observed.The 19Y-STR loci displayed high genetic polymorphisms in the Han population in Northeast China,indicating that these 19 loci were useful genetic markers for forensic personal identification and paternity testing.There were distinctions among 15 ethnic groups.The genetic distance between 15 ethnic groups were ranged from 0.000 9to 0.643 2,and the conclusion of cluster analysis and MDS analysis were similar to the ethnogeny research and ethnic migration history.Conclusion The 19Y-STR loci displayed high genetic polymorphisms in the Han population in Northeast China,and these 19 loci were useful genetic markers for forensic personal identification and paternity testing.
【CateGory Index】: R394
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