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《Chongqing Medicine》 2017-08
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Effects of galactooligosaccharide on the intestinal flora in premature rats

Chen Yuandong;Lu Hongyan;Chang Ming;Shan JiYan;Department of Pediatrics,the Affiliated Hospital of Jiangsu University;  
Objective To explore the effects of galactooligosaccharide on the intestinal flora in premature rats.MethodsPremature Sprague-Dawley rats were randomly divided into GOS group and control group.Premature rats in GOS group were feeding with GOS according 4g/kg by dropper for 14 d.At 7d and 14 d after feeding,the mental state and weight of rats were observed and recorded,the fresh feces in terminal rectum were collected to culture and count the number of colonies of bifidobacteria,lactobacillus,enterobacteria and enterococcus.Results Rats in GOS and the control group were normal growth during the administration period,mental state was not abnormal.Compared with the same time point of the control group,there was no significant difference in weight gain between the GOS group(P0.05).After feeding GOS for 7d,there was no statistically significant difference between the number of colonies of bifidobacteria,lactobacillus,enterobacteria and enterococcus(P0.05).After feeding GOS for 14 d,the number of colonies of bifidobacteria and lactobacillus increased significantly(P0.05),while the number of enterobacteria and enterococcus decreased significantly(P 0.05).Conclusion Galactooligosaccharide could promote the proliferation of bifidobacterium and lactobacillus,inhibit the growth and reproduction of enterobacteria and enterococcus,so regulate the balance of intestinal flora.
【Fund】: 江苏省临床医学专项基金(BL2012058);; 江苏大学临床医学专项基金(JDLCZX004)
【CateGory Index】: R722.6
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