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《Chongqing Medicine》 2017-12
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Meta analysis on diagnosis value of narrow band imaging and iodine staining in early esophageal cancer and precancerous lesions

Liao Bingjie;Jiang Zheng;Department of Gastroenterology,First Affiliated Hospital of Chongqing Medical University;  
Objective To systematically evaluate the value of narrow band imaging(NBI)and iodine staining in early diagnosis of esophageal cancer and precancerous lesions.Methods The databases of PubMed,Embase,CNKI,VIP technological journals and Wanfang digital journals were retrieved by computer for searching the literatures on the value of NBI and iodine staining in diagnosing early esophageal cancer and precancerous lesions.The Meta-Disc 1.4software was used to conduct the meta analysis and calculate the pooled sensitivity,specificity and 95% confidence interval(95% CI).Summary receiver operating characteristic(SROC)curve was drawn and the area under curve(AUC)was calculated,thus the diagnostic values of the two methods were evaluated.Results Totally 13 articles were included,including 975 patients.The pooled sensitivity and specificity for NBI were0.88(95%CI=0.86 to 0.90)and 0.79(95%CI=0.76 to 0.82).The pooled sensitivity and specificity for iodine staining were 0.95(95%CI=0.93 to 0.97)and 0.45(95%CI=0.40 to 0.49).AUC of SROC for the two methods were 0.938 6and 0.952 9respectively.There was no statistically difference in the AUC values between the two methods(Z=0.519,P0.05).Conclusion NBI and iodine staining are both effective ways in the diagnosis of early esophageal cancer and precancerous lesions.And both of them have a certain clinical value.
【CateGory Index】: R735.1
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