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《Chongqing Medicine》 2017-13
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Celecoxib down-regulates Apaf-1 protein expression for promoting learning and mem craniocerebral traumaory function recovery after in rats

Zhang Tao;Guo Jianfei;Xing Linlin;Zhang Jinling;Zhang Yuxin;Hebei Medical University Afficiated Xingtai People′s Hospital;Xingtai Medical College;Medical College,North China Institute of Technology;  
Objective To study the effect of celecoxib on learning and memory function,cyclooxygenase(COX-2)and the apoptotic protease-activating factor-1(Apaf-1)protein expression after traumatic brain injury in rat.Methods A total of 72 adult male Wistar rats were equally and randomly divided into the normal control group,sham operation group,trauma group and Celecoxib treatment group.Postoperative 72h-reperfusion was performed for taking brain specimens.The immunohistochemical method and Western blot were used to respectively detect COX-2and Apaf-1protein expression change;the Morris water maze test was adopted to detect the learning and memory function on preoperative 5dand at postoperative 72 h.Results The COX-2and Apaf-1protein expression in the trauma group was significantly higher than that in other groups(P0.05),and the protein expression in the treatment group and trauma group was decreased,but still higher than that in the sham operation group and normal group(P0.05);in the Morris water maze test,the prolongation of escape latency time in the trauma group was maximal among 4groups(P0.05),but the treatment group had a shorter time compared with the trauma group(P0.05).Conclusion Craniocerebral trauma can cause different degrees of learning and memory dysfunction,and COX-2inhibitor celecoxib can downregulate the expression of COX-2and Apaf-1protein,inhibit inflammation reaction and cellular apoptosis,and improve the learning and memory dysfunction after traumatic brain injury.
【Fund】: 河北省自然科学基金资助项目(C2004000689);; 河北省博士基金资助项目(05547008D-4);; 河北省科学技术与社会发展计划项目(04276135)
【CateGory Index】: R651.15
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