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《Chongqing Medicine》 2017-13
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Effect of dexmedetomidine on plasma SDF-1 levels in hepatic portal occlusion operation

Yang Zhen;Ning Jiaolin;Gu Jianteng;Yi Bing;Lu Kaizhi;Department of Anesthesiology,Southwest Hospital,Third Military Medical University;  
Objective To observe the effect of dexmedetomidine on plasma SDF-1level in in hepatic portal occlusion operation.Methods Fifty patients with live cancer undergoing elective partial hepatectomy were selected,no gender limitation,aged 42to71,body mass index(BMI)18.5 ~ 26.0kg/m~2,ASA gradeⅡ orⅢ.The patients were randomly divided into 2groups(n=25):control group and dexmedetomidine group.The dexmedetomidine group was performed the pump injection of dexmedetomidine1μg/kg at 15 min before induction of anesthesia.After induction the rate was changed to 0.4μg·kg~(-1)·h~(-1) until 15 min before the end of operation;the control group adopted the same method for conducting continuous intravenous infusion of the same capacity of 0.9% sodium chloride.The peripheral venous blood was collected in 2groups at preoperative 1h(T0),postoperative 1h(T1),postoperative 1d(T2),postoperative 3d(T3).The plasma SDF-1level was detected by using enzyme-linked immunosorbent assay(ELISA).Results There was no statistically significant difference in liver resection range,blood loss,first porta hepatis vessel occlusion time,anesthesia time and plasma SDF-1level before surgery between the two groups(P0.05).Compared with pre-operation,plasma SDF-1level at T1,T2,T3 time point was significantly increased(P0.05).The plasma SDF-1level at T1,T2,T3 time point in the dexmedetomidine group was lower than that in the control group(P0.05).Conclusion SDF-1expression is significantly increased during perioperative period in the patients with hepatic portal occlusion operation,and intraoperative continuous dexmedetomidine can significantly reduce the SDF-1level,which inhibits the chemotaxis and accumulation of inflammatory cells to some extent.
【Fund】: 国家自然科学基金资助项目(81270510)
【CateGory Index】: R614
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