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《Chongqing Medicine》 2017-13
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Expression and significance of platelet derived growth factor B and its receptorsαin skin lesions of recurrent condyloma acuminatum

Wang Jun;Chen Xiyin;Liu Wenbei;Chang Xiaoli;He Caifeng;Ji Bihua;Department of Dermatology,Yijishan Hospital of Wannan Medical College;  
Objective To investigate the expression of platelet-derived growth factor B(PDGF-B)and PDGFR-αmRNA in the skin lesion of recurrent condyloma acuminatum(CA)and to explore its relationship with recurrent condyloma acuminatum.Methods The expressions of PDGF-B and PDGFR-αmRNA in the lesions of recurrent CA and Nonrecurrent CA were investigated by Real-Time-PCR,and the normal foreskins were taken as controls.Results The PDGF-B and PDGFR-αmRNA levels in the recurrent CA group and non-recurrent CA group were significantly higher than those in the normal control group,the differences were statistically significant(P0.05).The expressions of PDGF-B and PDGFR-αmRNA in the recurrent CA group were higher than those in the non-recurrent CA group(P0.01).Furthermore,the expressions of PDGF-B and PDGFR-αmRNA before treatment in the recurrent CA group were higher than those after treatment(P0.01).Conclusion PDGF-B and PDGFR-αmRNA might haue a certain relation with CA recurrence.
【Fund】: 2013年度高校省级自然科学研究项目(KJ2013B324)
【CateGory Index】: R752.53
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LIN Jian-hua;LIANG Yue-ying;Laboratory Department,Fenggang Hospital of Dongguan City,Guangdong Province;;Assessment of cellular immune and humoral immune function of recurrent condyloma acuminatum patients and its correlation with associated molecule expression in skin lesions[J];海南医学院学报;2015-12
2 WANG Jun1,2,CUI Yong1,YANG Sen1,LIU Wen-pei2,CI Chao2,CHANG Xiao-li2,JI Bi-hua2(1 Department of Dermatology,First Hospital of Anhui Medical University,Hefei 230031,China;2 Department of Dermatology,Yijishan Hospital of Wannan Medical College,Wuhu 241001,China);Expression of Platelet Derived Growth Factor and Its Receptors in the Lesions of Patients with Condyloma Acuminatum[J];中国皮肤性病学杂志;2009-03
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 Wang Jun;Chen Xiyin;Liu Wenbei;Chang Xiaoli;He Caifeng;Ji Bihua;Department of Dermatology,Yijishan Hospital of Wannan Medical College;;Expression and significance of platelet derived growth factor B and its receptorsαin skin lesions of recurrent condyloma acuminatum[J];重庆医学;2017-13
2 XUE Kun;YANG Yanping;Department of Dermatology,Weinan Central Hospital;;Effects of 5-Fluorouracil Combined with CO_2 Laser on Genital Warts and Influence on Inflammatory Factors[J];医学综述;2017-08
3 WANG Shang-you;MI Xiong-fei;Affiliated Hospital of Chengdu University of Traditional Chinese Medicine;;The Clinical Research on Condyloma Acuminatum by Toli Xiaodu Powder(托里消毒散) and BCG Polysaccharide and Nucleic Acid Injection[J];中医药导报;2017-03
4 LI Zhifeng;LI Xiaojing;LI Lihong;LIU Baoguo;Department of Dermatology,Affiliated Hospital of Hebei Engineering University;Department of Dermatology,Handan Central Hospital,Hebei Province;;Effect of photodynamic therapy combined with carbon dioxide laser therapy for the expression of CD4~+,CD8~+T cells and regulatory T cells of peripheral blood in patients with recurrent condyloma acuminatum[J];中国医药导报;2016-23
5 LI Zhifeng;LI Lihong;LI Xiaojing;LIU Baoguo;Department of Dermatology, Affiliated Hospital of Hebei Engineering University;Department of Dermatology, Handan Central Hospital,Hebei Province;;Clinical study of three stage photodynamic therapy for the male patients with condylome acuminate[J];中国医药导报;2016-13
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 WANG Jian-lei;WEI Jia;WANG Qi;XU Hong-jun;HU Ya-hong;ZHAO Li-hua;Department of Dermatology,Civil Aviation General Hospital;Department of Pathology,Civil Aviation General Hospital;;Expression and Significance of FOXP3 in Skin Lesions from Patients with Condyloma Acuminatum[J];中国皮肤性病学杂志;2014-11
2 WANG Jian-lei;WANG Qi;XU Hong-jun;HU Ya-hong;FENG Hua;WANG Ting-lin;Department of Dermatology,Civil Aviation General Hospital;;Detection of CD4~+ CD25~+ Foxp3~+ Regulatory T cells in the Peripheral Blood of Patients with Condyloma Acuminatum and its Correlation with HPV Subtypes[J];中国皮肤性病学杂志;2014-06
3 LI Yan;ZHANG Shou-min;LI Zhen-lu;Henan Provincial People′s Hospital;;A study on correlation between human papillomavirus infection in patients with condyloma acuminatum and cellular immune function[J];中华医院感染学杂志;2014-12
4 JIN Hua;ZHANG Hong-ye;SHAN Ying;DONG Zheng-bang;PAN Yong-zheng;ZHANG Li-hua;WANG Fei;Department of Dermatology and Venereology,Hangzhou Xixi Hospital;Department of Dermatology and Venereology,the Affiliated Hospital of Southeast University;;Study on the Expression of p16,PCNA and CyclinD1 in Condyloma Acuminatum[J];中国皮肤性病学杂志;2013-10
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