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《Chongqing Medicine》 2017-14
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The effect of cigarette smoke exposure on nitric oxide level in testis of male rats

Zhang Jing;Deng Sheng;Zhong Chunxue;Huang Yunfei;Zhang Chen;He Lijuan;Zou Ying;Department of Toxicology,College of Public Health,Xinjiang Medical University;Xinjiang Center for Disease Control and Prevention;  
Objective To explore the effect of cigarette smoke exposure on testis structure and nitric oxide(NO)level in testis of rats.Methods A total of 160 adult male SD rats were divided into control group and low,medium,high dose groups.The smoke-exposed rats were respectively exposed to the smog for the periods of 2,4,6,8and 12 weeks,10rats in each group.The smoke-exposed rats were exposed to cigarette smoke for 0.5hper day.The testicular tissue structure was observed and the body mass and the NO level of testis were measured.Results Compared with the control group and low dose group,the body mass of the rats was significantly lower in the medium and high dose groups exposed for 4,6,8,12weeks(P0.05).Compared with the medium dose groups,the body mass of the rats was significantly lower in the high dose group exposed for 8weeks and 12weeks(P0.05).And with the increase of exposure dose,the reducing was even more obvious.Compared with the control group and low and medium dose groups,NO level in testis of rats was significantly increased in the high dose groups exposed for 2,4,6,8weeks(P0.05).Compared with the control group,NO level in testis of rats was significantly increased in the medium dose groups exposed for 8weeks(P0.05).Compared with the control group,NO level in testis of rats was significantly increased in the low,medium and high dose groups exposed for 12weeks(P0.05);and compared with the low dose group,NO level in testis of rats was significantly increased in the medium and high dose groups(P0.05).Conclusion Cigarette smoke exposure may have impacts on testis tissue and lead to the increase of NO level in testis of male rats.
【Fund】: 国家自然科学基金资助项目(81260433);; 新疆维吾尔自治区自然科学基金项目(2014211C015)
【CateGory Index】: R114
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1 Zhang Jing;Deng Sheng;Zhong Chunxue;Huang Yunfei;Zhang Chen;He Lijuan;Zou Ying;Department of Toxicology,College of Public Health,Xinjiang Medical University;Xinjiang Center for Disease Control and Prevention;;The effect of cigarette smoke exposure on nitric oxide level in testis of male rats[J];重庆医学;2017-14
2 ZHANG Jing;ZHONG Chun-xue;HUANG Yun-fei;ZHANG Chen;HE Li-juan;ZOU Ying;Department of Toxicology,College of Public Health,Xinjiang Medical University;;Effects of cigarette smoke on Tf mRNA and protein expression levels in testis of rats[J];环境与健康杂志;2016-11
3 ZHANG Jing;HUANG Yun-fei;ZHANG Chen;HE Li-juan;ZHONG Chun-xue;ZOU Yin;Department of Toxicology,College of Public Health,Xinjiang Medical University;;Effects of tobacco smoke on testis tissue and IGF-1 in male rats[J];毒理学杂志;2016-04
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