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《Chongqing Medicine》 2017-14
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The protective effects of Rhodiola rosea combined with vitamin E on the skeletal muscle through hypoxia combined with exercise training in mice

Pang Jutao;Zhang Xinhu;Sun Jianhua;Zhou Lianjun;Liu Bin;Li Fengguo;Liang Yuanyuan;Department of Orthopaedics,Hengshui Halison International Peace Hospital;Department of Orthopaedics,Liaoning Provincial Corps Hospital of Chinese People′s Armed Police Forces;  
Objective To study the protective effects of vitamin E combined with Rhodiola rosea on the injury in mice skeletal muscle through hypoxia with exercise training and research the mechanism of action.Methods Forty ICR mice were randomly divided into control group and observation group,20 mice in each group.The control group was given Vitamin E(40mg·kg~(-1)·d~(-1)),and the observation group was given Vitamin E(40 mg·kg~(-1)·d~(-1))combined with Rhodiola rosea(20g·kg~(-1)·d~(-1));the rats in the two groups were treated with hypoxia(11.3%)for 4weeks(5 ℃,15m/min,60min/d)after 15-day drug using.After the last training,all the mice were euthanized and then detected the gene of Bax and Bcl-2mRNA through the RT-PCR in the skeletal muscle and the activity of GSH-PX,SOD,ROS,the concentration of MDA in the skeletal muscle.During the period(pretrain and 1,2,4weeks)of hypoxia combined with exercise training,the CK,LDH in the serum were detected.ResultsThe expression of CK and LDH in the observation group were lower than those of the control group(P0.05).The activity of GSH-PX and SOD in the skeletal muscle of the observation group was significantly higher than that of the control group(P0.05),while the ROS and MDA were lower than those of the control group(P0.05);the expression of Bax mRNA and Bax/Bcl-2of the observation group was significantly lower than that of the control group(P0.05).While the expression of Bcl-2mRNA was significantly higher than that of the control group(P0.05).Conclusion Rhodiola rosea combined with Vitamin E can inhibit the expression of apoptotic genes by correcting the oxidation and hypoxia imbalance under hypoxia.
【CateGory Index】: R685.4
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