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《Chongqing Medicine》 2017-14
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The expression and correlation of MMP-9 and NF-κB in obstructive sleep apnea syndrome patients with hypertension

Tan Xiaoyan;Kuang Jiulong;Department of Respiratory,the Second Affiliated Hospital of Nanchang University;  
Objective To investigate the role of plasma matrix metalloproteinase-9(MMP-9)and nuclear factor kappa B(NF-κB)in the pathogenesis of obstructive sleep apnea hypopnea syndrome(OSAHS)complicated with hypertension.MethodsThe patients were selected in the respiratory medicine and neurology of our hospital from January 2014 to June 2014.Polysomnography(PSG)monitoring was employed to assess the patient.All patients were divided into 3groups,including snoring group(23cases),OSAHS group(32cases),OSAHS with hypertension group(31cases).And then according to the hypertension stage,OSAHS with hypertension group was divided into 3groups,including OSAHS with stage 1hypertension group(9cases),OSAHS with stage2 hypertension group(9cases),OSAHS with stage 3hypertension group(13cases).The plasma MMP-9was measured by ELISA.The mRNA expression levels of MMP-9and NF-κB were detected by real-time quantitative PCR.Results The levels of MMP-9and MMP-9mRNA and NF-κB mRNA in OSAHS with hypertension group were significantly higher than those of snoring group and OSAHS group and the differences were statistically significant(P0.05).The expression of MMP-9,the MMP-9and NF-κB mRNA expression of monocytes in OSAHS with stage 3hypertension group was significantly higher than those of OSAHS with stage 1hypertension group and OSAHS with stage 2hypertension group and the differences were statistically significant(P0.05).The plasma MMP-9was positively correlated with AHI and oxygen desaturation index and negatively correlated with LSaO2(P0.05).The plasma MMP-9was positively correlated with the MMP-9mRNA expression(P0.05).The MMP-9mRNA expression was positively correlated with the NF-κB mRNA expression(P0.05).Conclusion The plasma concentrations of MMP-9,the MMP-9and NF-κB mRNA expression of monocytes in OSAHS with hypertension patients was significantly high,which is associated with disease severity and degree of hypoxia.The MMP-9might play an important role in the pathogenesis of OSAHS with hypertension and be regulated by NF-κB pathway.
【Fund】: 江西省教育厅科学技术研究项目(14071)
【CateGory Index】: R563.9
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【Citations】
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【Co-citations】
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1 Tan Xiaoyan;Kuang Jiulong;Department of Respiratory,the Second Affiliated Hospital of Nanchang University;;The expression and correlation of MMP-9 and NF-κB in obstructive sleep apnea syndrome patients with hypertension[J];重庆医学;2017-14
2 YAN Ming-hua;LI Ruo-ran;DU Chang-jun;Department of Respiratory Medicine,Centeral Hospital of Xuzhou;;Effect of Continuous Positive Airway Pressure on Blood Pressure and Serum Leptin Level in Patients with Serve Obstructive Sleep Apnea Hypopnea Syndrome Accompanied by Hypertension[J];实用心脑肺血管病杂志;2014-10
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6 ZHANG Hu.China-Japan Friendship Hospital,Ministry of Public Health,Beijing 100029,China;Research Progress on the Relationship of Obstructive Sleep Apnea Hypopnea Syndrome and Hypertension[J];中国全科医学;2012-27
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