Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2017-14
Add to Favorite Get Latest Update

The influence of butylphthalide on the memory,movement and ERP in patients with cerebral infarction cognitive impairment

Jin Mei;Ma Shijiang;Shen Changbo;Wang Wensheng;Department of Neurology,the Third Affiliated Hospital of Xinxiang Medical University;Research Institute of Tuberculosis,the First Affiliated Hospital of Xinxiang Medical University;  
Objective To investigate the effect of butylphthalide on the memory,movement and ERP(event-related potentials)in patients with cerebral infarction cognitive impairment.Methods A total of 134 patients with cerebral infarction cognitive impairment were randomly divided into treatment group(67patients)and control group(67patients).All patients were given conventional cerebral infarction treatment as well as cognitive improvement intervention.Oral administration of butylphthalide was added onto the patients in the treatment group.Curative effects were observed after 30days′continued treatment.The cognitive function scores,memory scores,movement scores,ERP test and adverse reaction were compared between the two groups before and after treatment.Results After 30days′treatment,two groups of the montreal cognitive assessment scale(MoCA)scores were27.2±4.9and 25.1±4.1respectively;the total scores of memory were 5.5±0.5and 4.9±0.5respectively;the scores of motor assessment scale(Fugl-meyer)were 85.6±6.2and 74.2±6.1respectively and P3 amplitudes were(9.5±0.9)μV and(8.1±0.9)μV respectively.All the indexes mentioned above in treatment group were significantly increased compared with those of before treatment(P0.05).The results of N1,N2,P2 and P3in the latency detection were significantly decreased compared with those of before treatment(P0.05).And the results of P2 and P3in the latency detection of the treatment group were shorter than those of the control group(P0.05).After treatment,no adverse reaction was observed in both groups.Conclusion Based on conventional cerebral infraction treatment,oral administration of butyraldehyde effectively improve the therapeutic effect.
【Fund】: 河南省自然科学基金资助项目(162300410217);; 国家自然科学基金面上项目(31170733)
【CateGory Index】: R973.31
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 6 Hits
1 Yin Chunli;Wang Yaowu;Wang Liying;Department of Neurology,Affiliated Tangshan Municipal Worker's Hospital,Hebei Medical University;Department of Neurosurgery,Affiliated Tangshan Municipal Worker's Hospital,Hebei Medical University;;Influence of Butylphthalide Soft Capsules on hemodynamics in acute cerebral infarction[J];重庆医学;2013-26
2 YIN Chunli,LI Yong-qiu,WANG Yao-wu.Department of Neurology,Tangshan Gongren Hospital Affiliated to Hebei Medical University,Tangshan 063000,China;Influence of Butylphthalide soft capsules on ischemic penumbra in acute cerebral infarction[J];临床神经病学杂志;2013-03
3 WU Ying;ZHONG Ping;Department of Neurology,Shanghai TCM-Integrated Hospital;;Advances in silent brain infarction[J];国际脑血管病杂志;2013-05
4 Wu Juan,Chen Yong(Department of Geriatrics,Chongqing Municipal Third People′s Hospital,Chongqing 400014,China);Effects of Butylphthalide on clinical efficacy and hemorheology in patients with acute cerebral infarction[J];重庆医学;2012-33
5 LIU Nan-ping1,CHEN Jing-yun1,XIA Xian-jun3,SHA Yan-ni2,LING Shu-min2,PAN Zong1,SUN Hai-feng2(1.The Dep.of Neurophysiology,The General Cardiovascular Diseases Hospital of Ningxia Med.Univ.,Key Lab.of Brain Disease of Ningxia,Yinchuan 750004;2.The Department of Neurophysiology,The General Hospital of Ningxia Med.Univ.,Key Lab.of Brain Disease of Ningxia,Yinchuan 750004;3.Ningxia Med.Univ.,Yinchuan 750004);Evaluation of Event-related Potential P300 and TCD Detection on Cognitive Function of Multiple Cerebral Infarction[J];宁夏医科大学学报;2012-01
6 HUANG Xiaobo, WANG Ningqun, CHEN Wenqiang Dept.of Traditional Chinese Medicine,Xuanwu Hospital,Capital Medical University,Beijing,100053;Characteristics of cognitive disorder and emotional disorder in old patients with acute cerebral infarction[J];中国康复医学杂志;2011-07
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 ZHAO Shuqing;YU Lanlan;LIU Fei;Laiyuan County,Baoding City,Hebei Province Hospital of traditional Chinese Medicine;;Clinical Effect Study of Butylphthalide use for Treatment of Patients with Acute Lacunar Infarction[J];血栓与止血学;2017-04
2 LIU Yafang;HUANG Yongmei;DAI Jun;CAO Xiongbin;SHI Yunqiong;Department of Neurology,Huangshi Central Hospital of Edong Healthcare Group Affiliated Hospital of Hubei Polytechnic University;Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention;Huangshi Center for Disease Control and Prevention,Hubei Province;;Clinical efficacy of Butylphthalide in combination with Alprostadil Injection in the treatment of posterior circulation ischemic vertigo[J];中国医药导报;2017-18
3 YUAN Yong;Department of Rehabilitation, Xuzhou Mining Business Group General Hospital;;Curative effect by Xuesaitong injection combined with rosuvastatin in the treatment of diabetes complicated with cerebral infarction and its influence on neural function in patients[J];中国实用医药;2017-16
4 WU Wenqin;PI Haijv;QIN Xueqin;Emergency Department,Taihe Hospital of Shiyan City,Hubei;;Influence of Danshen injection adjunctive treatment on the therapeutic effects and SOD levels in patients with acute cerebral infarction[J];河北医药;2017-10
5 Jin Mei;Ma Shijiang;Shen Changbo;Wang Wensheng;Department of Neurology,the Third Affiliated Hospital of Xinxiang Medical University;Research Institute of Tuberculosis,the First Affiliated Hospital of Xinxiang Medical University;;The influence of butylphthalide on the memory,movement and ERP in patients with cerebral infarction cognitive impairment[J];重庆医学;2017-14
6 ZHOU Fengkun;MING Shaopeng;YANG Liqiang;Department of Neurology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine;Department of Anesthesiology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine;Department of Pain,Xuanwu Hospital,Capital Medical University;;Application of ozone major auto-hemo-therapy in acute ischemic stroke[J];中国医药导报;2017-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Guo-zhang,XU Zu-mei,LIN Zhi-jian,et al.Department of Neurology,Affiliated Hospital of Putian College,Putian 351100,China;Relationship between different matching of MR perfusion and diffusion weighted imaging and curative effects of defibrase treatment in acute cerebral infarction[J];临床神经病学杂志;2011-05
2 LI Qi-fu1,2,CHEN Zhi-bin1,WANG Shu-rong1,WANG Tan1,ZHOU Dong2,HE Li2(1.Department of Neurology,the Affiliated Hospital of Hainan Medical College,Haikou,Hainan,570102 P.R.China;2.Department of Neurology,West China Hospital,Sichuan University,Chengdu,Sichuan,610041 P.R.China);Effects of dl-3-n-butylphthalide on expression of Bcl-2 in rat brain after cerebral ischemia/reperfusion injury[J];华西药学杂志;2011-04
3 WAN He-ming,WANG Bin(Department of Neurology,Wuxi People′s Hospital,Wuxi 214023,Jiangsu Province,China);Effect of butylphthalide on serumal free radical and hemorheology in patients with vascular dementia[J];新乡医学院学报;2011-02
4 CUI Yu-huan1,ZHANG Chao-dong1,WEI Yu-lei2(1.Department of Neurology,The First Affiliated Hospital,China Medical University,Shenyang 110001,China;2.Department of Thoracic Surgery,Shengjing Hospital,China Medical University,Shenyang 110004,China);The Protective Effects of Butylphthalide on Amyloid β Peptide_(25-35) Induced Apoptosis in PC-12 Cells[J];中国医科大学学报;2010-06
5 SHI Hongmei(Department of Neurology,Jilin Neuropsychiatric Hospital,Siping 136000,China);Clinical efficacy observation and effects of Butylphthalide Injection on platelet aggregation in patients with cerebral infarction[J];中国医药导报;2010-17
6 WANG Ye,GU Shen-wei,ZHOU Zhan-hong,et al.(Yueyang Hospital Affiliated of Shanghai University of T.C.M,Shanghai 200437,China);Study of cerebral hemodynamics in mild cognitive impairment[J];中风与神经疾病杂志;2010-04
7 WANG Ningqun,LI Zongxin,Huang Xiaobo,et al.Dept.of Traditional Chinese Medicine,Xuanwu Hospital,Capital Medical University,Beijing,100053;Stroke-specific quality of life in ischemic stroke patients with cognitive disorder[J];中国康复医学杂志;2009-10
8 FENG Tao,WANG Yong-Jun.Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;The Current Views on Clinical Criteria for Vascular Dementia[J];中国卒中杂志;2009-01
9 Ya-Juan Hu,Kai Wang,Shan-Shan Zhou Department of Neurology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Advances in the Silent Stroke[J];国际脑血管病杂志;2008-07
10 LI Qi-fu,KONG Shuang-yan,DEJI Qu-zong,HE Li,ZHOU Dong.Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China;Effects of dl-3-n-butylphthalide on Expression of VEGF and bFGF in Rat Brain with Permanent Focal Cerebral Ischemia[J];四川大学学报(医学版);2008-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved