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《Chongqing Medicine》 2017-14
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Expression and significance of ABCG2 and ALDH1 in malignant transformation of ovarian endometriosis

Liu Songping;Tian Xin;Wen Jian;Yin Xinming;Department of Obstetrics and Gynecology,the Fourth Affiliated Hospital of Jiangsu University;  
Objective To investigate the expression and significance of ABCG2 and ALDH1in malignant transformation of ovarian endometriosis.Methods The protein expressions of ABCG2 and ALDH1were detected with immunohistochemistry in 38 cases of malignant transformation of ovarian endometriosis(EMs malignant transformation group),35 cases of endometriosis(EMs group)and 30 cases of normal endometrium(control group).Results The positive rates of ABCG2 and ALDH1expressions in EMs malignant transformation group were significantly higher than those in EMs group and control group(P0.05).The expressions of ABCG2 and ALDH1were significantly associated with the serum CA125 level,differentiation and clinical stage of malignant transformation of ovarian endometriosis(P0.05),but were not related to the patient′s age,dysmenorrhea history and pathology type(P0.05).There was no correlation between the expression of ABCG2 and ALDH1in malignant transformation of ovarian endometriosis(P0.05).Conclusion The expressions of ABCG2 and ALDH1might be involved in malignant transformation of ovarian endometriosis.
【Fund】: 江苏省自然科学基金资助项目(BK20140502);; 江苏省“六大人才高峰”资助项目(2015-WSW-088);; 吴阶平医学基金资助项目(320.6755.15023)
【CateGory Index】: R711.71
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