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《Chongqing Medicine》 2017-15
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The effect of different HAART regimens on liver function and HIV load of HIV infected children with HCV co-infection

Rao Heping;Jin Changzhong;Jin Xiangning;Fang Meixin;Wang Wei;Lu Weili;College of Medicine,Quzhou Vocational and Technical College;State Key Laboratory of Infectious Diseases Diagnosis,the First Affiliated Hospital of Zhejiang University Medical College;School of Medicine,Jinhua Vocational and Technical College;Department of Internal Medicine,Affiliated Children′s Hospital of Zhejiang University Medical College;Department of AIDS,Quzhou City Center for Disease Control and Prevention;Department of Infectious Diseases,Quzhou People′s Hospital;  
Objective To investigate the effect of different HAART regimens on liver function,viral load and CD4~+T cells of HIV infected children with HCV co-infection.Methods A total of 40 patients were divided into 4groups:13cases in AZT+3TC+NVP group(group A),16 cases in AZT+3TC+EFV group(group B),5cases in D4T+3TC+EFV group(group C)and 6cases in D4T+3TC+NVP group(group D).Liver function,viral load and CD4~+T cells of patients in 4groups were compared between before and after HAART.Results Eight patients(20%)had abnormal liver function before HAART treatment,and all of them had1 level of liver damage.After receiving HAART,levels of ALT and AST were increased in group A and B(P0.01);AST levels were increased in group C(P0.01).CD4~+T counts were all increased and HIV viral loads were decreased in 4groups(P0.01).There was no significant difference in RNA HCV load before and after HAART treatment(P0.05).Conclusion Different HAART regimens can increase the liver damage in HIV infected children co-infected with HCV,but have little effect on the treatment efficiency of HAART regimens.
【Fund】: 浙江省公益性技术应用研究计划项目(2014C33252);; 衢州市科技计划项目(2013Y019)
【CateGory Index】: R725.1
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1 Rao Heping;Jin Changzhong;Jin Xiangning;Fang Meixin;Wang Wei;Lu Weili;College of Medicine,Quzhou Vocational and Technical College;State Key Laboratory of Infectious Diseases Diagnosis,the First Affiliated Hospital of Zhejiang University Medical College;School of Medicine,Jinhua Vocational and Technical College;Department of Internal Medicine,Affiliated Children′s Hospital of Zhejiang University Medical College;Department of AIDS,Quzhou City Center for Disease Control and Prevention;Department of Infectious Diseases,Quzhou People′s Hospital;;The effect of different HAART regimens on liver function and HIV load of HIV infected children with HCV co-infection[J];重庆医学;2017-15
2 HU Shui-xiu;HUANG Kui;WEI Xiu-bai;QIN Shan-fang;HUANG Wei;Guangxi Zhuang Autonomous Region Longtan Hospital;;Immunological effect of highly active antiretroviral therapy for AIDS in 5 years[J];中华医院感染学杂志;2017-10
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