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《Chongqing Medicine》 2017-15
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Effect of topical application of tranexamic acid on blood loss and safety of total hip arthroplasty

Wang Jian;Li Yehai;Xu Junjie;Second Department of Orthopaedics Chaohu Hospital Affiliated to Anhui Medical University;  
Objective To study the effect of topical application of tranexamic acid(TXA)in total hip arthroplasty(THA).Methods A total of 63 patients with unilateral THA were enrolled in this study from November 2014 to March 2016.All patients were randomly divided into group A(n=37)and group B(n=26).Group A was injected with 2.0g TXA(dissolved in 10 mL saline)in the joint cavity tube after the end of the surgical dressing.Group B injected the same amount of saline.The hemoglobin,hematocrit,postoperative blood loss,blood transfusion,blood transfusion and replacement of 24,48,72 hafter the replacement,24,48 and 72hafter fibrinogen,prothrombin time and activation of part of the thromboplastin time,lower extremity deep vein ultrasound between the two groups were compared.Results The hemoglobin,hematocrit,postoperative blood loss,blood transfusion and blood transfusion were significantly better in group A than those in group B at 24,48 and 72hafter replacement(P0.05).There was no significant difference in fibrinogen,prothrombin time and activated partial thromboplastin time between the two groups before and after replacement for 24,48,72h(P0.05).Conclusion The local application of TXA group can significantly reduce the THA perioperative blood loss without the increase of the risk of deep vein thrombosis.
【CateGory Index】: R687.4
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Chinese Journal Full-text Database 1 Hits
1 XI Shao-hua;ZHOU Chao-bo;ZHAO Gui-lin;The Second Orthopaedics Department,The Second Affiliated Hospital of Xingtai Medical College;;Hemostatic effect of local application and intravenous application of tranexamic acid in total knee arthroplasty[J];实用药物与临床;2015-04
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