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《Chongqing Medicine》 2017-15
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Effect of topical application of tranexamic acid on blood loss and safety of total hip arthroplasty

Wang Jian;Li Yehai;Xu Junjie;Second Department of Orthopaedics Chaohu Hospital Affiliated to Anhui Medical University;  
Objective To study the effect of topical application of tranexamic acid(TXA)in total hip arthroplasty(THA).Methods A total of 63 patients with unilateral THA were enrolled in this study from November 2014 to March 2016.All patients were randomly divided into group A(n=37)and group B(n=26).Group A was injected with 2.0g TXA(dissolved in 10 mL saline)in the joint cavity tube after the end of the surgical dressing.Group B injected the same amount of saline.The hemoglobin,hematocrit,postoperative blood loss,blood transfusion,blood transfusion and replacement of 24,48,72 hafter the replacement,24,48 and 72hafter fibrinogen,prothrombin time and activation of part of the thromboplastin time,lower extremity deep vein ultrasound between the two groups were compared.Results The hemoglobin,hematocrit,postoperative blood loss,blood transfusion and blood transfusion were significantly better in group A than those in group B at 24,48 and 72hafter replacement(P0.05).There was no significant difference in fibrinogen,prothrombin time and activated partial thromboplastin time between the two groups before and after replacement for 24,48,72h(P0.05).Conclusion The local application of TXA group can significantly reduce the THA perioperative blood loss without the increase of the risk of deep vein thrombosis.
【CateGory Index】: R687.4
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 XI Shao-hua;ZHOU Chao-bo;ZHAO Gui-lin;The Second Orthopaedics Department,The Second Affiliated Hospital of Xingtai Medical College;;Hemostatic effect of local application and intravenous application of tranexamic acid in total knee arthroplasty[J];实用药物与临床;2015-04
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 Wang Jian;Li Yehai;Xu Junjie;Second Department of Orthopaedics Chaohu Hospital Affiliated to Anhui Medical University;;Effect of topical application of tranexamic acid on blood loss and safety of total hip arthroplasty[J];重庆医学;2017-15
2 GAO Hong-liang;HUANG Sheng;GUAN Guo-hua;WU Feng-feng;LI Jian-you;Dept of Orthopaedics,Huzhou Central Hospital;;The impact and safety analysis in different using mode of tranexamic acid of blood loss after total knee arthroplasty[J];临床骨科杂志;2016-05
3 Hou Jinlong;Department of Orthopedics,Zhengzhou Coal Group General Hospital;;Effects of long-range and short-range hemostasis on swelling,bleeding and thrombosis after total knee arthroplasty[J];中国实用医刊;2016-19
4 Zhao Liang;Liu Jing;Fang Jie;Lei Junxiang;Hu Juntao;Cao Kai;Lan Bingxin;Department of Pharmacy,Xuchang Central Hospital,Henan Province;Department of Infection Management,Xuchang Central Hospital,Henan Province;Department of Pharmacy,Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine;;Clinical effect of antibiotics during perioperative period of primary total hip/knee arthroplasty[J];中国医药;2016-10
5 LIN Xiangbo;WANG Jianran;LI Changhui;WANG Daixian;CHEN Bo;Department of Joint Surgery, People’s Hospital of Rizhao;;Clinical Study of Topical Application of Tranexamic Acid Blood Quantity and Safety of Primary Unilateral Knee Replacement in Perioperative Period[J];中国继续医学教育;2016-19
6 Lin Ye;Zhang Guo-liang;Wang Yue-wen;Inner Mongolia Medical University;Department of Orthopedics,Affiliated Hospital of Inner Mongolia Medical University;;Application and safety of tranexamic acid in total knee arthroplasty[J];中国组织工程研究;2016-09
7 Deng Yingjie;Meng Fufen;Xiang Wenyuan;Fang Rui;Hospital of TCM Affiliated to Xinjiang Medical University;Tumor Hospital Affiliated to Xinjiang Medical University;;Application of Tranexami Acid in Blood Management for Total Knee Arthroplasty Perioperative in 40 Cases[J];中国药业;2015-24
8 Deng Yingjie;Meng Fufen;Fang Rui;Xiang Wenyuan;Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University;Tumor Hospital Affiliated to Xinjiang Medical University;;Perioperative Application of Tranexami Acid on Blood Management for Total Knee ArthroPlasty in 40 Cases[J];中国药业;2015-21
【Secondary Citations】
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1 Hu Xudong;ZhouZongke;Pei Fuxing;Ma Jun;Shen Bin;Yang Jing;Kang Pengde;Department of Orthopaedics,West China Hospital Sichuan University;;Perioperative efficiency and safety of different regimen of tranexamic acid on total knee arthroplasty[J];中华骨科杂志;2014-06
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3 ZOU Yong-gen;ZHANG Jian;YANG Jie-xiang;Department of Fracture and Wounds, Affiliated Traditional Chinese Medicine Hospital of Luzhou Medical College;;Effects of the administration of erythropoietin-alpha before total knee arthroplasty on patients with mild anemia[J];实用医学杂志;2014-04
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5 LUO Ji-wei1,JIN Da-di1,HUANG Mei-xian2,LIAO Hua2,XU Da-chuan2 Department of Orthopedics and Spinal Surgery,Nanfang Hospital1,Department of Anatomy2,Southern Medical University,Guangzhou 510515,China;Evaluation of perioperative blood loss following total knee arthroplasty[J];南方医科大学学报;2006-11
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