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《Chongqing Medicine》 2017-15
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Clinical research of Xin bao drug edible of herbal medicine granule on coronary heart disease with heat-blood stagnation syndrome

Li Dongyu;Li Hanbing;Wu Suhui;Xuan Jingjing;Department of Internal Medicine,Zhengzhou Hospital of Traditional Chinese Medicine;College of Pharmacy,Henan University of Traditional Chinese Medicine;  
Objective To observe the effect of drug edible of herbal medicine granule on vascular endothelial function in patients with coronary heart disease(CHD).Methods A total of 200 cases featuring with cardiovascular blood stasis were chosen from patients who were diagnosed with CHD in Zhengzhou hospital of traditional Chinese medicine from January 2015 to January2016.All cases were divided into observation group(n=98)and control group(n=102).The observation group was given Xin bao drug edible of herbal medicine granule and conventional drugs,and the control group was given conventional drugs.After 8weeks of observation,the levels of endothelin(ET-1),nitric oxide(NO)and angiotensin Ⅱ(AngⅡ)were measured by enzyme-linked immunosorbent assay(ELISA).The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),and TCM clinical symptom score were compared between the two groups.Results The level of TC of the control group was decreased after treatment(P0.05);the levels of TC,TG and LDL in the observation group were lower than those in the control group(P0.05).After treatment,the levels of NO,ET-1,Ang-Ⅱ and FMD in the observation group were significantly different from those before treatment(P0.05).The levels of NO and FMD in the observation group were higher than those in the control group,and the levels of ET-1and Ang-Ⅱ were lower than those in the control group(P0.05).After treatment,the scores of TCM clinical symptoms in the observation group were lower than those before treatment(P0.05).Compared with the control group,the total score of palpitations,the times of shortness of breath and clinical symptoms were lower than those in the observation group(P0.05).Conclusion Xin bao drug edible of herbal medicine granule could relieve coronary heart disease blood stasis type of patients with vascular tension,reduce its endothelial cell damage and improve its clinical symptoms.
【Fund】: 2015年郑州市科技局项目(20150122);; 河南中医学院科技创新人才项目(2015XCXRC02)
【CateGory Index】: R259
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