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《Chongqing Medicine》 2017-15
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IL-6 gene rs1800796 polymorphism and febrile seizures susceptibility:a Meta analysis

Li Zhen;Mei Wenlong;Chai Yanting;Mao Haiyu;Luo Min;Child Health Care Center,Shiyan Municipal Maternal and Child Health Care Hospital;  
Objective To systematically evaluate the association between IL-6gene rs1800796 polymorphism and febrile seizures(FS)susceptibility.Methods The related literatures on IL-6gene rs1800796 polymorphism and febrile seizures(FS)susceptibility were retrieved from PubMed,Web of Science Embase,Cochrane Library,CNKI,WanFang,VIP and CBM Databases by computer.ORand its 95%CI were taken as the pooled effects.The RevMan 5.2software was adopted to conduct the statistical analysis.The publication bias analysis was performed by using the STATA12.0software.Results Seven independent case-control studies were included according to the inclusion and exclusion standard,involving 516 accumulated cases and 528 controls.The results showed that IL-6gene rs1800796 polymorphism had a significant association with FS susceptibility in Chinese population(GG+CG vs.CC:OR=2.22,P=0.05;G vs.C:OR=2.44,P0.01;GG vs.CC:OR=3.69,P=0.03;GG vs.CG+CC:OR=3.43,P0.01).The subgroup analysis was conducted according to possible important confounding factors,and the results showed that this gene polymorphism had a significant association with FS susceptibility in Chinese population(GG+CGvs.CC:OR=3.32,P0.01;Gvs.C:OR=3.23,P0.01;GGvs.CC:OR=7.27,P0.01;GGvs.CG+CC:OR=5.17,P0.01:CGvs.CC:OR=2.56,P=0.02).But in other populations,except recessive model(GGvs.CG+CC:OR=2.40,P0.01),all other genetic models did not display obvious correlation.The subgroup analysis was conducted by FS diagnostic standard,and the results showed that this gene polymorphism had a significant correlation with infantile FS onset in diagnosing FS by the Chinese standard(GG+CGvs.CC:OR=4.57,P0.01;Gvs.C:OR=4.36,P0.01;GGvs.CC:OR=12.75,P0.01;GGvs.CG+CC:OR=8.60,P0.01:CGvs.CC:OR=3.40,P0.01).Conclusion IL-6gene rs1800796 polymorphism may be associated with infantile FS susceptibility and allele G may be a risk factor for FS onset.
【CateGory Index】: R720.597
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WU Hui;ZHANG Wuqiang;LI Jun;XU Nanping;KE Jiangwei;Department of Emergency, the Children's Hospital of Jiangxi Province;Department of Pediatrics, the People's Hospital of Ruichang City;;Study on the IL-6 polymorphism and NSE level in children with febrile seizures[J];中国医药导报;2014-33
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【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 Li Zhen;Mei Wenlong;Chai Yanting;Mao Haiyu;Luo Min;Child Health Care Center,Shiyan Municipal Maternal and Child Health Care Hospital;;IL-6 gene rs1800796 polymorphism and febrile seizures susceptibility:a Meta analysis[J];重庆医学;2017-15
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