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《Chongqing Medicine》 2017-15
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Efficacy of liraglutide in the treatment of nonalcoholic fatty liver disease:a Meta analysis

Li Hong;Pu Shiyun;Liu Qinhui;Huang Xin;Kuang Jiangying;Chen Lei;Shen Jing;Cheng Shihai;Wu Tong;Li Yanping;Mo Li;Jiang Wei;He Jinhan;Department of Clinical Pharmacy,West China Hospital,Sichuan University;Department of Clinical Pharmacy and Drug Adverse Reaction,Sichuan University;Department of Geriatrics,West China Hospital,Sichuan University;Molecular Medicine Research Center/State Key Laboratory of Biotherapy,West China Hospital,Sichuan University;  
Objective To evaluate the efficacy of liraglutide in the treatment of Nonalcoholic Fatty Liver Disease(NAFLD).Methods Randomized controlled trials(RCTs)that evaluated the efficacy of liraglutide for NAFLD treatment were searched in multiple databases,including Pubmed,EMBASE,the Cochrane library,CNKI,Wanfang database and VIP.Literature identification and data extraction were based on the inclusion and exclusion criteria.RevMan 5.3software was used for Meta-analysis.Results A total of 7RCTs with 500 patients of NAFLD were included.Improved liver histology,or improved the level of alanine aminotransferase[WMD=-25.32,95%CI(-37.22,-13.41),P0.01]and aspartate aminotransferase[WMD =-24.56,95%CI(-35.10,-14.03),P0.01]were seen in 12-48 weeks liraglutide treatment.However,liraglutide could not decreased the level of serum cholesterol[WMD=-14.38,95%CI(-48.95,-20.20),P=0.42]and triglyceride[WMD=-15.55,95%CI(-36.20,-5.10),P=0.14].Conclusion liraglutide has the therapeutic effect of NAFLD.
【CateGory Index】: R575.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 QIU Wei-zhong;SHI Zhi-zhou;YE Xiu-wen;Ciyu Community Health Center of Longgang District People's Hospital;;Liraglutide improves lipid metabolism in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease[J];华夏医学;2015-01
2 Jia Xiao, Rui Guo, Man Lung Fung, Emily C Liong and George L Tipoe Departments of Anatomy, Physiology, and Research Centre of Heart, Brain, Hormone and Healthy Aging Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Gene and Cell Engineering Research Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges[J];Hepatobiliary & Pancreatic Diseases International;2013-02
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Li Hong;Pu Shiyun;Liu Qinhui;Huang Xin;Kuang Jiangying;Chen Lei;Shen Jing;Cheng Shihai;Wu Tong;Li Yanping;Mo Li;Jiang Wei;He Jinhan;Department of Clinical Pharmacy,West China Hospital,Sichuan University;Department of Clinical Pharmacy and Drug Adverse Reaction,Sichuan University;Department of Geriatrics,West China Hospital,Sichuan University;Molecular Medicine Research Center/State Key Laboratory of Biotherapy,West China Hospital,Sichuan University;;Efficacy of liraglutide in the treatment of nonalcoholic fatty liver disease:a Meta analysis[J];重庆医学;2017-15
2 Cai Xiaoqi;Cai Yuanyuan;Xie Hongdan;Digestive and Liver Department of Internal Medicine,Hainan Province Hospital of Traditional Chinese Medicine;;Clinical Observation of 124 Cases of Nonalcoholic Fatty Liver Disease Treated with Modified Two Chen Four Ingredients Decoction[J];世界中医药;2017-02
3 Li Junhan;Su Quansheng;Sun Junzhi;Zhang Zhongyang;Chengdu Sport University;Beijing Sport University;;Exercise and Diet Modification Delays Liver Cell Apoptosis of Rats with Endoplasmic Reticulum Stress Mediated Nonalcoholic Fatty Liver Disease[J];中国运动医学杂志;2017-01
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6 Xu-Jia Chen;Lan-Qing Ma;Department of Gastroenterology the First Affiliated Hospital of Kunming Medical University Yunnan Institute of Digestive Disease;;Role of farnesoid X receptor in nonalcoholic fatty liver disease[J];世界华人消化杂志;2015-08
7 Bojan Stanimirov;Karmen Stankov;Momir Mikov;Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad;Clinical Centre of Vojvodina, Faculty of Medicine, University of Novi Sad;School of Pharmacy, Curtin University;;Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases[J];Hepatobiliary & Pancreatic Diseases International;2015-01
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Sun WuanLu;Cao Haixiao;Fan Jiangao;Department of Gastroenterology,Xinhua Hospital,Shanghai Jiaowng University School of Medicine;;Diagnosis and treatment of non-alcoholic fatty liver disease[J];中华肝脏病杂志;2014-09
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