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《Chongqing Medicine》 2017-16
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Influence of gestational vitamin A deficiency on liver lipid synthesis in offspring of rats

Wei Xiaoping;Zhou Jing;Wang Hongying;Chen Jie;Xiao Xiaoqiu;Li Tingyu;Children′s Nutition Research Center,Children′s Hospital of Chongqing Medical University;Ministry of Education Key Laboratory of Child Development and Disorders;Outpatient Department,Children′s Hospital of Chongqing Medical University;Laboratory of Lipid & Glucose Metabolism,The First Affiliated Hospital of Chongqing Medical University;  
Objective To investigate the influence of gestational vitamin A(VA)deficiency on lipid synthesis in offspring liver tissue by using the rat model of gestational vitamin A deficiency.Methods The rat model of gestational VA deficiency was established and divided into the normal AV,VA deficiency and VA deficiency and supplement(VAD)groups.The offspring blood lipid levels were detected.The mRNA expression changes of lipid synthesis molecule ACC1,FAS and SREBP1 in liver were detected;the lipid droplet deposition situation after HE staining in offspring liver tissue section was observed.Results The HDL-C level of the VAD group was significantly lower than that of the VA normal group(VAN group and VAS group,P0.05),and the difference between the VAN group and VAS group had no statistical difference(P0.05).The TG level had statistically significant difference among the three groups(P0.05).The ACC1,FAS and SREBP1 mRNA expression levels in the VAD group were significantly increased.The liver in the VAD group appeared more lipid droplet deposit with partial lipid droplet vacuoles in cytoplasm;while the liver cells in the VAS and VAN groups showed the regular arrangement without obvious lipid droplet deposit.Conclusion Gestational VA deficiency may induce the abnormal activation of liver lipid synthesis pathway in rat offspring and causes lipid metabolic disturbance.
【Fund】: 国家自然科学基金资助项目(81602844);; 重庆市自然科学基金资助项目(CSTC 2010BB5370)
【CateGory Index】: R714
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