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《Chongqing Medicine》 2017-16
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Protective effects of total flavonoids extraction from ficus lacor leaves on A549 cells

Wang Yang;Hu Kui;Chen Ling;Su Yan;Ma Jiahui;Xiao Hong;Bai Qunhua;Experimental Teaching Center,Chongqing Medical University;Department of Occupational Health Examination,Guangdong Provincial Hospital of Occupational Injury Rehabilitation;Chongqing Medical University;Teand Researching Section of Health Inspection,Preventive Medicine,Chongqing Medical University;Teand Researching Section of Health Inspection,School of Public Health and Management,Chongqing Medical University;  
Objective To investigate the extraction method of total flavonoids from the leaves of ficus lacor and the protective effects of extraction on the cellular damage to provide a basis for the research on the phamaceutical value of ficus lacor leaves.Methods The ethanol extraction method was adopted to extract the total flavonoids in the leaves of ficus lacor and the extraction efficiency was calculated with rutin as the standard.The rotenone induced human lung adenocarcinoma cellular damage served as the model,then the influences of the extraction on the cellular viability,cellular morphology,production of reactive oxygen species(ROS)and apoptosis were researched.Results The extraction efficiency of total flavonoids in the leaves of ficus lacor by 60%ethanol was 5.02%;the extraction at the concentration of 32 mg/L could significantly inhibit the decrease of cell viability,cellular shape change,ROS production and apoptosis of A549 cells induced by 100μg/L rotenone.Conclusion The ethanol extraction method can be used to extract the total flavonoids in the leaves of ficus lacor and the extraction has the protective effects on the A549 cellular damage induced by rotenone,the leaves of ficus lacor have the potential for further researching its pharmaceutical value.
【Fund】: 重庆市科委前沿与应用基础研究计划项目基金(cstc2014jcyjA10019);; 重庆医科大学大学生科学研究与创新项目基金(201306);; 重庆市创新创业计划项目(201310631007)
【CateGory Index】: R285
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