Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2017-16
Add to Favorite Get Latest Update

A case-control study on risk factors for intrauterine HBV infection

Li Xiang;Hu Chao;Wang Taiwu;Zhang Yao;Li Yafei;Teaching and Research Section of Epidemiology,College of Preventive Medicine,Third Military Medical University;  
Objective To explore the risk factors for hepatitis B virus(HBV)intrauterine infection to provide a scientific evidence for its prevention.Methods Three hundred and twelve pregnant women of HBsAg positive screened from April 2013 to May2015served as the research subjects and were followed up until 6months after birth.The infantile mothers of HBsAg and/or HBV DNA positive were selected as the intrauterine infection case group,while other mothers served as the control group.The Logistic regression analysis was adopted to analyze the risk factors for intrauterine HBV infection.The questionnaire survey method was used to collect the basic data and time-resolved immunofluorescence assay was used to detect HBsAg.PCR was adopted to measure level of HBV DNA and automatic biochemistry analyzer was used to measure the hepatic functional parameters including ALT,AST,triglyceride and cholesterol.Results The single factor analysis results indicated that HBeAg,HBV DNA,contamination of amniotic fluid and sexual behavior during pregnancy were related to HBV intrauterine infection(P0.05).The multiple variate Logistic regression results showed that positive HBeAg(OR=2.76,95%CI=1.19-7.94),positive HBV DNA(OR=9.62,95%CI=2.58-35.33),and sexual behaviors during pregnancy(OR=1.53,95%CI=1.07-6.40)were the risk factors for intrauterine HBV infection.Conclusion Pregnant women with positive HBeAg,positive HBV DNA and sexual behavior during pregnancy may be the high risk factors for neonatal intrauterine HBV infection.
【Fund】: 国家自然科学基金资助项目(81202220)
【CateGory Index】: R714.251
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved