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《Chongqing Medicine》 2017-16
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Survival analysis of unresectable advanced pancreatic cancer after high intensity focused ultrasound therapy

Zhang Zhe;Jin Chengbing;Zhou Kun;Ran Lifeng;Yang Wei;School of Biomedical Engineering,Chongqing Medical University;Tumor Center,Second Affiliated Hospital of Chongqing Medical University;  
Objective To observe the 2-year survival situation of high intensity focused ultrasound(HIFU)treatment in unresectable advanced pancreatic carcinoma.Methods Thirty-eight patients with unresectable pancreatic cancer received HIFU treatment.After treatment,the changes of laboratory tumor markers examination results,pain score,life quality score and survival situation were recorded.Results Among 35 patients with pain symptom before HIFU treatment,pain was relieved after HIFU treatment in 28 cases,the remission rate was 80.0%.The CA19-9and CEA levels after HIFU therapy were obviously reduced compared with before treatment.The imaging examination showed the coagulation necrosis in HIFU-treated area.It was found the tumor volume was obviously shrunk during follow-up period.The median survival period was extended to(12.9±6.6)months.ConclusionThe HIFU treatment can effectively improve the life quality in the patients with unresectable pancreatic cancer and extends their survival period.
【Fund】: 国家重点基础研究发展计划(973计划)资助项目(2011GB707900)
【CateGory Index】: R735.9
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