Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2017-16
Add to Favorite Get Latest Update

Study on efficacy and safety of sequential rivaroxaban use in reducing blood loss after applying tranexamic acid in total hip arthroplasty

Li Fulin;Yin Dong;Mo Bingfeng;Huang Yu;Huang Xiao;Lu Qiang;Liu Wenhui;Guangxi Medical University;Department of Orthopedics,People′s Hospital of Guangxi Zhuang Autonomous Region;Wuhan University;  
Objective To research the efficacy and safety of sequential rivaroxaban use in reducing blood loss after applying tranexamic acid(TXA)in total hip arthroplasty(THA).Methods According to the design by the random control principle,150 patients undergoing unilateral primary THA from September 2012 to June 2015 were selected and randomly divided into the group A,B,C,D and E(n=30).The group A did not use TXA,the group B received intravenous drip of 10mg/kg TXA at 10 min before skin incision,the group C received intravenous drip of 15mg/kg TXA at 10 min before skin incision,the group D respectively received intravenous drip of 15mL/kg TXA at 10 min before skin incision and after 3h,the group E received intravenous drip of 15mL/kg TXA at 10 min before skin incision and articular cavity use of 1g TXA before closing the incision.Oral 10 mg rivaroxaban was given at postoperative 6-12 hwhen the drainage volume was less than 30mL/h and then the conventional dose was used until postoperative 35 d.The intraoperative blood loss,postoperative drainage volume,hidden blood loss,blood transfusion rate,postoperative anticoagulation time,time of removing drainage tube,postoperative prothrombin time on postoperative 1d,activated partial thromboplastin time,descend value of hemoglobin,and occurrence rates of postoperative deep vein thrombosis(DVT)and pulmonary embolism(PE)were observed in the group A,B,C,D and E.Results The intraoperative blood loss,postoperative drainage volume,hidden blood loss,blood transfusion rate and descend value of hemoglobin on postoperative 1dhad statistical differences among 5groups(P0.05).The are significant differences between the group D and A in the intraoperative blood loss,postoperative drainage volume,hidden blood loss,blood transfusion rate,descend value of hemoglobin on postoperative 1d,postoperative anticoagulation time and removal drainage tube time(P0.05).All cases had no symptomatic DVT and PE during the perioperative period and postoperative 3-month outpatient or telephone follow-up.Conclusion Sequential rivaroxaban use after applying TXA during THA perioperative period is safe and effective.Moreover intravenous drip of 15mL/kg TXA at 10 min before skin incision and after 3hhas most significant effect in reducing bleeding volume during THA perioperative period.
【Fund】: 广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z2016597)
【CateGory Index】: R687.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved