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《Chongqing Medicine》 2017-16
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Study on relationship between serum resistin,leptin and adiponectin with microangiopathy in patients with type-2 diabetes mellitus

Wang Likun;Yang Zhanqing;Zhang Jun;Yang Ruimin;Wu Xueliang;Shi Li;Wang Yicheng;Department of Ultrasonic Medicine,the First Hospital Affiliated to Hebei North University;Department of Internal Medicine,Kangbao County Hospital of Traditional Chinese Medicine;Department of Internal Medicine,the People′s Hospital of Qiaoxi District in Zhanjiakou City;Department of Vascular Gland Surgery,the First Hospital Affiliated to Hebei North University;Department of Endocrinolog,the First Hospital Afftliated to Hebei North University;  
Objective To investigate the relationship between serum resistin,leptin and adiponectin with microangiopathy in the patients with type-2diabetes mellitus(T2DM).Methods One hundred and twenty patients with T2 DM in our hospital were selected and divided into the non-microangiopathy group(NON-MAP,60cases)and microangiopathy group(MAP,60cases)according to whether complicating microangiopathy.Other 60 individuals undergoing healthy physical examination were selected as the normal control group(NC).Fasting serum resistin,adiponectin and leptin levels were detected in each group.Fasting blood glucose,insulin and blood lipid levels were also detected.The insulin resistance was evaluated by using insulin resistance index(HOMA-IR).Results The levels of serum resistin,leptin,free fat acid(FFA)and hs-CRP in the NON-MVP group and MVP group were significantly higher than those in the NC group,while the adiponectin level was significantly lower than that in the NC group,the difference was statistically significant(P0.05).The correlation analysis showed that serum resistin and leptin levels had positive correlation with hs-CRP,FFA,HOMA-IR and TG(P0.05),and had negative correlation with HDL-C(P0.05);the adiponectin level was negatively correlated with hs-CRP,FFA,HOMA-IR and TG,while positively correlated with HDL-C(P0.05);serum resistin and leptin levels had positive correlation,both had significantly negative correlation with adiponectin;with serum resistin,leptin and adiponectin as the dependent variables,the multiple stepwise linear regression analysis showed that HOMA-IR and waist to hip ratio had maximal influence on them.Conclusion Serum resistin and leptin levels increase and adiponectin level decrease in T2 DM patients suggests that serum resistin,leptin and adiponectin are correlated with T2 DM occurrence as well as microangiopathy occurrence.
【Fund】: 河北省卫生和计划生育委员会医学科学研究重点课题计划(20160367)
【CateGory Index】: R587.2
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