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《Chongqing Medicine》 2017-16
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Relationship between tumor metastasis with T cell subsets and cytokines in patients with primary hepatocellular carcinoma

Hu Conggang;Tang Guojun;Wang Jianjun;Tong Qin;Department of Gastrointestinal Surgery,Jinhua Guangfu Hospital;  
Objective To investigate the correlation between tumor metastasis with T cell subsets and cytokines in the patients with primary hepatocellular carcinoma(HCC).Methods Ninety-seven cases of primary HCC were prospectively collected from January 2014 to January 2016 and assigned into the metastasis group(38cases)and non-metastasis group(59cases)according to whether suffering from metastasis.Surgical specimens were obtained from all patients and flow cytometry was used to detect the CD4+,CD8+T cell proportion in HCC tissue,paracancerous tissues and peripheral blood.Moreover,ELISA was adopted to detect the peripheral blood IL-6,IL-10,TNF-αand IFN-γlevels.Results Compared with the non-metastasis group,the CD4+T cell proportion of HCC tissue in the metastasis group was significantly increased(P=0.02),while the CD8+T cells were significantly decreased(P=0.015).There was no statistical difference in CD4+T cells proportion in the paracancerous tissue between the two groups(P=0.328).However the CD8+T cells proportion of paracancerous tissue in the metastasis group was significantly higher than that in the non-metastasis group(P=0.021).There was no statistically significant difference in the proportion of CD8+T cells in peripheral blood of the two groups(P=0.362).The proportion of CD4+T cells in peripheral blood of the metastatic group was significantly lower than that in non-metastasis group(P=0.032).When compared with non-metastasis group,the metastasis group got a decreased level of peripheral blood IL-6(P=0.012);while the IL-10 level was significantly increased(P=0.006);the TNF-αlevel and IFN-γlevel were significantly decreased(P=0.000,P=0.035).Conclusion The patients with primary HCC have obvious T cell subsets and cytokines imbalance.
【CateGory Index】: R735.7
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