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《Chongqing Medicine》 2017-16
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Analysis on correlation between serum pentraxin 3 and metabolic indices in patients with type 2 diabetes mellitus

Yu Jianshen;Yang Hua;Yang Xiaodong;Rao Lihua;Liu Yuntao;Department of Clinical Laboratory,Renhe Hospital of Three Gorges University;  
Objective To investigate the change of serum pentraxin3 level in different body mass indices groups among the patients with type 2diabetes mellitus(T2DM)and to analyze its correlation with metabolic indices.Methods A total of 164T2 DM patients were divided into the normal body mass group(A,n=53),over-weight group(B,n=56)and obese group(C,n=55)according to BMI.Serum pentraxin3 level was assayed by ELISA.Then the relationship between serum pentraxin3 levels with BMI,blood glucose,blood lipid andHOMA-IR was analyzed.Results The pentraxin3 levels in the group A,B and C were(3.46±0.19),(2.47±0.21),(1.44±0.18)ng/mL respectively,the pairwise comparison among three groups showed the statistical difference(P0.05).The pentraxin3 level was negatively correlated with BMI,TG,LDL-C,FINS and HOMA-IR(r=-0.897,-0.621,-0.232,-0.593,-0.487,P0.05 or P0.01).The multiple stepwise regression analysis showed that BMI and HOMA-IR were independently correlated with serum pentraxin3 level.Conclusion BMI and HOMA-IR are the independent risk factor for affecting serum pentraxin3 level in T2 DM patients.
【CateGory Index】: R446.1;R587.1
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