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《Chongqing Medicine》 2017-16
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Maternal and neonatal perinatal outcomes in pregnancies after in vitro fertilization and natural pregnancy:a systematic:a meta analysis

Long Ling;He Liren;Ye Chuan;Li Yuyan;He Wei;Reproductive Medicine Center,Southwest Hospital;77627 Troop Hospital,Lasa,Xizang;  
Objective To systematically evaluate maternal perinatal complications and neonatal outcomes after in vitro fertilization and embryo transplantation(IVF-ET).Methods The computer retrieval was performed on the databases of PubMed,Cochrane library,EMbase,CNKI,Wanfang and Chinese biomedical literature database.The articles on the comparison between IVF and natural pregnancy were included.The RevMan5.3software was adopted to conduct the meta analysis.Results Twenty-three articles conforming to the requirements were included,including 1 312 651 cases,among them 113 044 cases were IVF and 1 199607 cases were natural pregnancy.IVF mother′s age was larger than that of natural pregnancy,while the gestational weeks were smaller than those of natural pregnancy,the newborn birth weight was lighter than that of natural pregnancy(P0.05);the probability of pregnancy-induced hypertension(PIH),placenta previa,postpartum hemorrhage and gestational diabetes mellitus(GDM)occurrence in IVF mother were higher than that of natural pregnancy(P0.05);the rate of multiple and cesarean section in IVF mothers were higher than that of natural pregnancy(P0.05);the occurrence rates of small for gestational age(SGA),low birth weight infants,stillbirth and premature in IVF were higher than those of natural pregnancy(P0.05).Conclusion The maternal perinatal complications in IVF are higher than those of natural pregnancy,and the birth outcomes in IVF are worse than those of natural pregnancy.
【Fund】: 2015年默克雪兰诺中国生殖医学研究基金(CREATE基金)资助(WX20115-015)
【CateGory Index】: R714.8
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