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《Chongqing Medicine》 2017-16
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Oral tranexamic acid tablet for assisted treatment of melasma:a Meta analysis

Liu Limei;Chen Hua;Xie Mengyao;Cao Guoxiu;Yuan Yonghua;Department of Pharmacy,Children′s Hospital of Chongqing Medical University;Pediatric Research Institute,Children′s Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders;Chongqing Key Laboratory of Pediatrics;Teaching and Researchin Section of Clinical Pharmacy,Chongqing Medical University;China International Science and Technology Cooperation Base of Child Development and Critical Disorders;Department Dermatology,Children′s Hospital of Chongqing Medical University;  
Objective To evaluate the efficacy and safety of hemostatic tranexamic acid tablet in the treatment of chloasma.Methods Such databases as PubMed,EBSCO,ISI Web of Science,Cochrane Library(Issue 12,2015)CENTRAL,VIP,CNKI Wanfang Database were electronically retrieved from their establishment to January 7,2016 for seeking the randomized controlled trials(RCTs)on tranexamic acid tablet in treating melasma.Two valuators independently screened the literatures,extracted the data and evaluated the quality of included RCTs.The meta analysis was performed by using Stata 12.0software.Results Sixteen RCTs were included,simultaneously involving the efficiency in the two groups(n=13)the severity score(n=5),adverse reactions(n=14)and the recurrence situation(n=4).(1)The difference of curative effect between the two groups was statistically significant[OR=2.49,95%CI(1.39,4.46),P=0.002];(2)the total effective rate[r5=0.75,95%CI(0.69,0.82),P=0.000];the total effective rate[r6=0.93,95%CI(0.91,0.95,P=0.005];(3)when the course of treatment was 8weeks,the curative effect score in the tranexamic acid group was lower than that in the control group[SMD=-1.23,95%CI(-1.38,-1.08),P=0.000],and the difference was statistically significant;(4)4articles reported the adverse reactions.The main adverse reaction types were gastrointestinal reactions and menstruation volume decrease.3articles reported the number of recurrent cases,and 1article reported the rate of recurrence.Conclusion The curative effect in the tranexamic acid treatment group in treating chloasma is better than that in the control group;oral tranexamic acid tablet has the reliable safety in the treatment of chloasma,but there is recurrence situation.
【CateGory Index】: R758.42
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