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《Chongqing Medicine》 2017-18
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Comparative analysis on short-term efficacies of two kinds of artifical liver method in treating severe hepatitis B

He Xiaofeng;Luo Ling;Yuan Chunlan;Jiang Zuli;Department of Infectious Diseases,Second Affiliated Hospital of Chongqing Medical University;  
Objective To investigate the short-term efficacy of plasma exchange(PE),PE combined with double plasma molecule absorption system(PE+DPMAS)for treating severe hepatitis B(SHB).Methods The clinical data in 70 patients with SHB were retrospectively analyzed.The patients were divided into the PE group and PE+DPMAS group according to different treatment modes.The clinical symptoms,liver function,coagulation function,blood routine,renal function and electrolytes changes,score decrease of model for end-stage liver disease(MELD)before and after treatment were compared between the two groups.Results After treatment,the alimentary tract symptoms were improved,the grade of hepatic encephalopathy was reduced and MELD score was decreased,but there was no statistically significant difference in the short-term effective rate between the two groups(P0.05).After treatment ALT,TBIL,RBC,Hb and PLT in the two groups were decreased significantly(P0.05);the ALB level in the PE+DPMAS group was decreased,while K+and Cl-were increased(P0.05);the PTA and ALB levels in the PE group were increased,while WBC was decreased in the PE group(P0.05).Conclusion The two kinds of treatment method PE and PE+DPMAS are effective in treating SHB.PE+DPMAS can reduce the plasma usage and improve serum K~+,Cl~-levels;PE is superior to PE+DPMAS in the aspects of improving coagulation function and ALB level.
【Fund】: 重庆市卫生和计划生育委员会基金资助项目(20112154)
【CateGory Index】: R512.62
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