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《Chongqing Medicine》 2017-18
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Effects of stem cells transplantation on immune function,liver function and related indexes in patients with end-stage liver disease

Wu Yuzhuo;Yang Le;Zhai Yufeng;Zhang Huaihong;Huo Liya;Department of Infection,Nanyang Municipal Central Hospital,Affiliated Hospital of Zhengzhou University;Department of Basic Medicine,Nanyang Medical College;  
Objective To investigate the effect of stem cells transplantation on immune function,liver function and related indexes in the patients with end-stage liver disease(ESLD).Methods A total of 163 cases of ESLD in Nanyang Municipal Central Hospital of Affiliated Hospital of Zhengzhou University were selected and divided into 2groups by the randomized single blind method.Eighty-one cases in the control group were given the conventional symptomatic treatment,while 82 cases in the observation group received bone marrow mesenchymal stem cell(BMSC)transplantation based on the control group.The changes of immune function,liver function,alpha fetoprotein(AFP),rate of prothrombin activity(PTA)and plasma total protein(TP)level before and after treatment were observed in the two groups.Results The immune function indexes CD3~+,CD4~+,CD8~+,CD4~+/CD8~+,TP and PTA levels after treatment in the observation group were significantly higher than those before treatment and in the control group(P0.05),while the levels of AFP,alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)were lower than those before treatment in the same group and the control group(P0.05).There was no statistically significant difference in complication occurrence rate between the two groups(P0.05).Conclusion BMSC transplantation for treating ESLD can improve the immune function,improves the liver function and reduces the AFP level.
【Fund】: 河南省卫生厅科研成果项目[宛科鉴字(2012)第103号99]
【CateGory Index】: R575.3
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