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《Chongqing Medicine》 2017-18
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Effects of stem cells transplantation on immune function,liver function and related indexes in patients with end-stage liver disease

Wu Yuzhuo;Yang Le;Zhai Yufeng;Zhang Huaihong;Huo Liya;Department of Infection,Nanyang Municipal Central Hospital,Affiliated Hospital of Zhengzhou University;Department of Basic Medicine,Nanyang Medical College;  
Objective To investigate the effect of stem cells transplantation on immune function,liver function and related indexes in the patients with end-stage liver disease(ESLD).Methods A total of 163 cases of ESLD in Nanyang Municipal Central Hospital of Affiliated Hospital of Zhengzhou University were selected and divided into 2groups by the randomized single blind method.Eighty-one cases in the control group were given the conventional symptomatic treatment,while 82 cases in the observation group received bone marrow mesenchymal stem cell(BMSC)transplantation based on the control group.The changes of immune function,liver function,alpha fetoprotein(AFP),rate of prothrombin activity(PTA)and plasma total protein(TP)level before and after treatment were observed in the two groups.Results The immune function indexes CD3~+,CD4~+,CD8~+,CD4~+/CD8~+,TP and PTA levels after treatment in the observation group were significantly higher than those before treatment and in the control group(P0.05),while the levels of AFP,alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)were lower than those before treatment in the same group and the control group(P0.05).There was no statistically significant difference in complication occurrence rate between the two groups(P0.05).Conclusion BMSC transplantation for treating ESLD can improve the immune function,improves the liver function and reduces the AFP level.
【Fund】: 河南省卫生厅科研成果项目[宛科鉴字(2012)第103号99]
【CateGory Index】: R575.3
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 SU Dong-Na;WU Shi-Pin;Department of Infectious Diseases,Shenzhen People' s Hospital,the Second Clinical Medicine College,Jinan University;;Experimental research of therapeutic effect of Smad7 gene modified bone marrow mesenchymal stem cells on liver cirrhosis rats[J];中国免疫学杂志;2016-05
2 Jiang Hui;Gao Jiarong;Wang Yongzhong;Zhang Jiafu;Han Yanquan;Wei Liangbing;Liu Xiaochuang;Wu Jian;Department of Pharmacy, the First Affiliated Hospital of Anhui University of Chinese Medicine;Grade Three Laboratory of Traditional Chinese Medicine Preparation, State Administration of Traditional Chinese Medicine;;Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/Stat3 pathways[J];Journal of Traditional Chinese Medicine;2016-02
3 Xu Linglong;Wu Dijiong;Shao Keding;The First Clinical Medical School of Zhejiang Chinese Medical University;;Human Bone Marrow-derived Mesenchymal Stem Cells Down-regulate CD8~+T Cells and Th1-associated Cytokines in Patients with Immune Thrombocytopenia:An in vitro Study[J];浙江中医药大学学报;2016-04
4 ZHANG Chao;LI Hong-yu;GUO Xiao-zhong;WANG Di;ZHANG Ning-ning;Gastrointestinal Department of Internal Medicine General Hospital of Shenyang Military Area ommand;;Analysis of the Clinical Efficacy of Autologous Bone Marrow Stem Cell Transplantation in the Treatment of Decompensated Cirrhosis[J];现代生物医学进展;2015-10
5 LEI Xiang-li,TONG Ming-hua,ZHANG Jian,WANG Ya-ping,KONG Xiang-ping.Center of Hepatic Diseases,No.458 Hospital of the People's Liberation Army,Guangzhou Guangdong 510602,China;Effect of Different Transplantation Methods of Bone Marrow Mesenchymal Stem Cells on Rats with Liver Cirrhosis[J];华南国防医学杂志;2012-03
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 Wu Yuzhuo;Yang Le;Zhai Yufeng;Zhang Huaihong;Huo Liya;Department of Infection,Nanyang Municipal Central Hospital,Affiliated Hospital of Zhengzhou University;Department of Basic Medicine,Nanyang Medical College;;Effects of stem cells transplantation on immune function,liver function and related indexes in patients with end-stage liver disease[J];重庆医学;2017-18
2 ZHANG Chun-yan;TAO Zhong-hua;CHEN Chuan-ning;GAN Lin;Southwest Medical University;;Puerarin prevents hepatic stellate cells from acetaldehyde stimulated apoptosis through downregulating TGFβ[J];时珍国医国药;2017-04
3 GAO Chunmei;Department of Transfusion,The First People's Hospital in Shangqiu;;The Effect of Different Programs on the Level of T cells in Peripheral Blood of Patients With Primary Immune Thrombocytopenia[J];中国继续医学教育;2016-28
4 YANG Xia-tong;XU Ming;GUO Wan-wei;FU Yan-yu;Department of Digestive Medicine,the Second People’s Hospital of Guangdong;;Application of relevance between liver-derived stem cells and liver cancer[J];东南国防医药;2014-03
5 Liao Hao;Sun Yi;Chen Qing;Min Min;Jing Xinrong;Zhong Guocheng;Center of Hematology and Oncology,Hospital 452 of PLA;Outpatient Department,Southwest Institute of Electronic and Telecommunication Technology;;Curative effects of autologous peripheral stem cell transplantation and sequential NK cells therapy on multiple myeloma[J];西南国防医药;2013-12
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Guo Chunhui;Han Lanxiu;Wan Meirong;Deng Guojiong;Gan Jianhe;The First Affiliated Hospital of Soochow University;;Effect and mechanism of Bone Marrow Mesenchymal Stem Cells on autologous lymphocyte proliferation in patients with decompensated liver cirrhosis[J];中华实验和临床病毒学杂志;2015-02
2 FENG Jia;XIANG Yang;XIA Yan;CAI Jie;CHEN An-Ping;YANG Nian-An;GONG Shu-Shi;LIU Dong-Mei;YUAN Lin;Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases of Hubei University for Nationalities;;Effect of Yiqiyangyin Decoction on pulmonary fibrosis rat and expression of Smad2/Smad7 protein[J];中国免疫学杂志;2015-03
3 GAN Xin-rong;TIAN Li;ZHANG Zhi-jian;Department of Infections,Chongqing Banan District People's Hospital;Department of ICU,Chongqing Banan District People's Hospital;;Research Progress on the Correlation between Cell Signaling Pathway and Liver Fibrosis[J];医学综述;2014-22
4 Deng Wujian;Xiang Guangyang;Cheng Lin;Yu Kun;Chen De;Department of Surgey,The Second Affiliated Hospital of Guangzhou Medical University;Department of Surgey, Huidong People's Hospital;;The effect of hepatic oval cell transplantation on TGFβ / smad signaling transduction in rats with hepatic cirrhosis[J];岭南现代临床外科;2014-03
5 ZHAO Xia;DING Hui-fang;GUO Cheng-shan;LU Xi-jing;XU Min;XING Jian;HAN Fang;WANG Liang;LU Guang;LIU Guo-qiang;Department of Hematology,the Central Hospital of Shengli Oil Field;;In vitro effects of mesenchymal stem cells on secreting function of T lymphocytes and CD4~+CD25~+ T cells from patients with immune thrombocytopenia[J];中华血液学杂志;2013-12
6 SUN Xin,GAO Rui-lan,LIN Xiao-jie, XU Wei-hong,and CHEN Xiao-hong 1.Department of Oncology,Zhejiang Provincial People's Hospital,Hangzhou(310014),China;2.Institution of Hematology Research,The First Affiliated Hospital,Zhejiang Chinese Medical University,Hangzhou(310006),China;Panax Notoginseng Saponins Induced Up-Regulation,Phosphorylation and Binding Activity of MEK,ERK,AKT,PI-3K Protein Kinases and GATA Transcription Factors in Hematopoietic Cells[J];Chinese Journal of Integrative Medicine;2013-02
7 GUO Xin-hong1,ZHAO Fang1,SHI Wei1,MA Xiu-min2,XU Qi2,PATIGULI·A-bu-li-zi1,HALIDA Ya-sen1 1Department of Hematology,First Affiliated Hospital,Xinjiang Hematological Research Institute;2State Key Laboratory Incubation Base of Xinjiang Major Diseases Research,Xinjiang Medical University,Urumqi 830054,China;Detection and clinical significance of Th1/Th2 cytokines in patients with idiopathic thrombocytopenic purpura[J];细胞与分子免疫学杂志;2012-11
8 ZHOU Wei△,XU Yan-hua,WU Xiao-ling,JIANG Rong,CHEN Peng-fei(△Department of Gastroenterology,The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China);In Vivo Induction of Differentiation of Rat Bone Marrow Mesenchymal Stem Cells into Myofibroblasts[J];中国生物制品学杂志;2011-05
9 HE Yao1,XIONG Li-shou1,HUANG Wen-sheng2,YANG Rong-ping1,CHEN Yu-jun1,REN Ming1(1Department of Gastroenterology,2Minimal Invasive Surgery,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China.);Mesenchymal stem cells contribute to the formation of liver fibrosis[J];中国病理生理杂志;2010-08
10 Wang Dong-xu, Jiang Hai-xing, Su Si-biao, Qin Shan-yu, Liang Zi-yu Department of Digestion, First Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China;Influence of bone marrow mesenchymal stem cells on hepatic stellate cells proliferation:Regulation of Cyclin D1 and P27 expression[J];中国组织工程研究与临床康复;2010-10
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